Human Granzyme H (GZMH) activation kit by CRISPRa

CAT#: GA102037

GZMH CRISPRa kit - CRISPR gene activation of human granzyme H

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: GZMH
• Locus ID: 2999
• Kit Components:

  GA102037G1, Granzyme H gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102037G2, Granzyme H gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102037G3, Granzyme H gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270780, NM_001270781, NM_033423
• UniProt ID: P20718
• Synonyms: CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
• Summary: This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]