Human Ku70 (XRCC6) activation kit by CRISPRa

CAT#: GA101691

XRCC6 CRISPRa kit - CRISPR gene activation of human X-ray repair cross complementing 6

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: XRCC6
• Locus ID: 2547
• Kit Components:

  GA101691G1, Ku70 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101691G2, Ku70 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101691G3, Ku70 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001288976, NM_001288977, NM_001288978, NM_001469
• UniProt ID: P12956
• Synonyms: CTC75; CTCBF; G22P1; KU70; ML8; TLAA
• Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]