Human EGFR activation kit by CRISPRa

CAT#: GA101355

EGFR CRISPRa kit - CRISPR gene activation of human epidermal growth factor receptor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: EGFR
• Locus ID: 1956
• Kit Components:

  GA101355G1, EGFR gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101355G2, EGFR gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101355G3, EGFR gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005228, NM_201282, NM_201283, NM_201284, NM_001346897, NM_001346898, NM_001346899, NM_001346900, NM_001346941
• UniProt ID: P00533
• Synonyms: ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
• Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]