Human BCL2 activation kit by CRISPRa

CAT#: GA100410

BCL2 CRISPRa kit - CRISPR gene activation of human BCL2 apoptosis regulator

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: BCL2
• Locus ID: 596
• Kit Components:

  GA100410G1, BCL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100410G2, BCL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100410G3, BCL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000633, NM_000657
• UniProt ID: P10415
• Synonyms: Bcl-2; PPP1R50
• Summary: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]