Angpt2 (NM_134454) Rat Tagged ORF Clone Lentiviral Particle

CAT#: RR201008L4V

Lenti ORF particles, Angpt2 (GFP-tagged ORF) - Rat angiopoietin 2 (Angpt2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Rat Tagged ORF Clone
• Tag: mGFP
• Symbol: Angpt2
• Synonyms: Agpt2; Ang-2
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_134454
• ORF Size: 1488 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RR201008).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_134454.1, NP_604449.1
• RefSeq Size: 2296 bp
• RefSeq ORF: 1491 bp
• Locus ID: 89805
• UniProt ID: O35462
• Cytogenetics: 16q12.5
• Gene Summary: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).[UniProtKB/Swiss-Prot Function]