SIRP alpha (SIRPA) (NM_001040022) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC222380L2V

Lenti ORF particles, SIRPA (mGFP-tagged) - Human signal-regulatory protein alpha (SIRPA), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC222380L2 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC222380L2V particle to overexpress human SIRPA-mGFP fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: SIRPA
• Synonyms: BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_001040022
• ORF Size: 1515 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC222380).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_001040022.1
• RefSeq Size: 4201 bp
• RefSeq ORF: 1515 bp
• Locus ID: 140885
• UniProt ID: P78324
• Cytogenetics: 20p13
• Protein Families: Druggable Genome, Phosphatase, Transmembrane
• MW: 54.8 kDa
• Gene Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]