Tryptophan Hydroxylase (TPH1) (NM_004179) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC221254L1V

Lenti ORF particles, TPH1 (Myc-DDK tagged) - Human tryptophan hydroxylase 1 (TPH1), 200ul, >10^7 TU/mL

Product Images

RC221254L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC221254L1V particle to overexpress human TPH1-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: Tryptophan Hydroxylase
• Synonyms: TPRH; TRPH
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_004179
• ORF Size: 1332 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC221254).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004179.1
• RefSeq Size: 1335 bp
• RefSeq ORF: 1335 bp
• Locus ID: 7166
• UniProt ID: P17752
• Cytogenetics: 11p15.1
• Domains: biopterin_H, ACT
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Tryptophan metabolism
• MW: 50.8 kDa
• Gene Summary: This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]