Cytochrome P450 2C9 (CYP2C9) (NM_000771) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC220997L2V

Lenti ORF particles, CYP2C9 (mGFP-tagged) - Human cytochrome P450, family 2, subfamily C, polypeptide 9 (CYP2C9), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: Cytochrome P450 2C9
• Synonyms: CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_000771
• ORF Size: 1470 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC220997).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000771.2
• RefSeq Size: 1835 bp
• RefSeq ORF: 1473 bp
• Locus ID: 1559
• UniProt ID: P11712
• Cytogenetics: 10q23.33
• Domains: p450
• Protein Families: Druggable Genome, P450
• Protein Pathways: Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism
• MW: 55.4 kDa
• Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]