ITCH (NM_031483) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC220408L2V

Lenti ORF particles, ITCH (mGFP-tagged) - Human itchy E3 ubiquitin protein ligase homolog (mouse) (ITCH), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: ITCH
• Synonyms: ADMFD; AIF4; AIP4; NAPP1
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_031483
• ORF Size: 2586 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC220408).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_031483.3
• RefSeq Size: 6357 bp
• RefSeq ORF: 2589 bp
• Locus ID: 83737
• UniProt ID: Q96J02
• Cytogenetics: 20q11.22
• Domains: C2, HECT, WW
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Endocytosis, Ubiquitin mediated proteolysis
• MW: 98.5 kDa
• Gene Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]