CrkRS (CDK12) (NM_016507) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC213898L2V

Lenti ORF particles, CDK12 (mGFP-tagged)-Human cyclin-dependent kinase 12 (CDK12), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: CDK12
• Synonyms: CRK7; CRKR; CRKRS
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_016507
• ORF Size: 4470 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC213898).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_016507.1
• RefSeq Size: 5515 bp
• RefSeq ORF: 4473 bp
• Locus ID: 51755
• UniProt ID: Q9NYV4
• Cytogenetics: 17q12
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• MW: 164.2 kDa
• Gene Summary: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.[UniProtKB/Swiss-Prot Function]