MCOLN2 (NM_153259) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC211195L2V

Lenti ORF particles, MCOLN2 (mGFP-tagged) - Human mucolipin 2 (MCOLN2), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: MCOLN2
• Synonyms: TRP-ML2; TRPML2
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_153259
• ORF Size: 1698 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC211195).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_153259.2
• RefSeq Size: 3060 bp
• RefSeq ORF: 1701 bp
• Locus ID: 255231
• UniProt ID: Q8IZK6
• Cytogenetics: 1p22.3
• Protein Families: Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
• MW: 65.9 kDa
• Gene Summary: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]