REA (PHB2) (NM_007273) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210710L4V

Lenti ORF particles, PHB2 (mGFP-tagged) - Human prohibitin 2 (PHB2), transcript variant 2, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: REA
• Synonyms: BAP; Bap37; BCAP37; p22; PNAS-141; REA
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_007273
• ORF Size: 897 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210710).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_007273.3, NP_009204.1
• RefSeq Size: 1457 bp
• RefSeq ORF: 899 bp
• Locus ID: 11331
• Cytogenetics: 12p13.31
• Domains: Band_7
• Protein Families: Druggable Genome, Transcription Factors
• MW: 33.3 kDa
• Gene Summary: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).[UniProtKB/Swiss-Prot Function]