GNA11 (NM_002067) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC210292L1V

Lenti ORF particles, GNA11 (Myc-DDK tagged) - Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), 200ul, >10^7 TU/mL

Product Images

RC210292L1 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC210292L1V particle to overexpress human GNA11-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: GNA11
• Synonyms: FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2
• Mammalian Cell Selection: None
• Vector: pLenti-C-Myc-DDK
• ACCN: NM_002067
• ORF Size: 1077 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210292).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002067.1
• RefSeq Size: 4145 bp
• RefSeq ORF: 1080 bp
• Locus ID: 2767
• UniProt ID: P29992
• Cytogenetics: 19p13.3
• Protein Pathways: Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Vascular smooth muscle contraction
• MW: 42.1 kDa
• Gene Summary: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]