FGFR4 (NM_002011) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC204230L3V

Lenti ORF particles, FGFR4 (Myc-DDK tagged) - Human fibroblast growth factor receptor 4 (FGFR4), transcript variant 1, 200ul, >10^7 TU/mL

Product Images

RC204230L3 was used to prepare Lentiviral particles using TR30037 packaging kit. HEK293T cells were transduced with RC204230L3V particle to overexpress human FGFR4-Myc-DDK fusion protein.

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: FGFR4
• Synonyms: CD334; JTK2; TKF
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_002011
• ORF Size: 2406 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204230).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_002011.3
• RefSeq Size: 3040 bp
• RefSeq ORF: 2409 bp
• Locus ID: 2264
• UniProt ID: P22455
• Cytogenetics: 5q35.2
• Domains: pkinase, TyrKc, S_TKc, ig, IGc2, IG
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton
• MW: 87.95 kDa
• Gene Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]