AGA (NM_000027) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC201975L4V

Lenti ORF particles, AGA (mGFP-tagged) - Human aspartylglucosaminidase (AGA), transcript variant 1, 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: AGA
• Synonyms: AGU; ASRG; GA
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_000027
• ORF Size: 1038 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC201975).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_000027.2, NP_000018.1
• RefSeq Size: 2113 bp
• RefSeq ORF: 1041 bp
• Locus ID: 175
• UniProt ID: P20933
• Cytogenetics: 4q34.3
• Domains: Asparaginase_2
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome, Other glycan degradation
• MW: 37.2 kDa
• Gene Summary: This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]