BAP1 (NM_004656) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC200378L2V

Lenti ORF particles, BAP1 (mGFP-tagged) - Human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Symbol: BAP1
• Synonyms: hucep-6; HUCEP-13; UCHL2
• Mammalian Cell Selection: None
• Vector: pLenti-C-mGFP
• ACCN: NM_004656
• ORF Size: 2187 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200378).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_004656.2
• RefSeq Size: 3717 bp
• RefSeq ORF: 2190 bp
• Locus ID: 8314
• UniProt ID: Q92560
• Cytogenetics: 3p21.1
• Domains: Peptidase_C12
• Protein Families: Druggable Genome, Protease
• MW: 80.4 kDa
• Gene Summary: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]