Pappa (NM_021362) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR227070L3V

Lenti ORF particles, Pappa (Myc-DDK-tagged) - Mouse pregnancy-associated plasma protein A (Pappa), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: Myc-DDK
• Symbol: Pappa
• Synonyms: 8430414N03Rik; IGFBP-4ase; PAG1; PAPP-A
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_021362
• ORF Size: 4872 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR227070).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_021362.1, NP_067337.1
• RefSeq Size: 11027 bp
• RefSeq ORF: 4875 bp
• Locus ID: 18491
• UniProt ID: Q8R4K8
• Cytogenetics: 4 34.14 cM
• Gene Summary: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected.[UniProtKB/Swiss-Prot Function]