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Pias3 (NM_018812) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR220934L4V
- LentiORF®
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Lenti ORF particles, Pias3 (GFP-tagged) - Mouse protein inhibitor of activated STAT 3 (Pias3), transcript variant 2, 200ul, >10^7 TU/mL
Lentiviral Particles: DDK w/ Puro
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USD 365.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | mGFP |
| Symbol | Pias3 |
| Synonyms | Pias3l |
| Mammalian Cell Selection | Puromycin |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_018812 |
| ORF Size | 1779 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR220934).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018812.2, NP_061282.2 |
| RefSeq Size | 2833 bp |
| RefSeq ORF | 1782 bp |
| Locus ID | 229615 |
| UniProt ID | O54714 |
| Cytogenetics | 3 F2.1 |
| Gene Summary | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity).[UniProtKB/Swiss-Prot Function] |
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