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Wtap (NM_001113532) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR218322L3V
- LentiORF®
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Lenti ORF particles, Wtap (Myc-DDK-tagged) - Mouse Wilms' tumour 1-associating protein (Wtap), transcript variant 3, 200ul, >10^7 TU/mL
Lentiviral Particles: mGFP w/ Puro
AAV Particle: DDK
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USD 365.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Symbol | Wtap |
| Synonyms | 2810408K05Rik; 9430038B09Rik |
| Mammalian Cell Selection | Puromycin |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001113532 |
| ORF Size | 453 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218322).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001113532.1, NP_001107004.1 |
| RefSeq Size | 4919 bp |
| RefSeq ORF | 456 bp |
| Locus ID | 60532 |
| UniProt ID | Q9ER69 |
| Cytogenetics | 17 A1 |
| Gene Summary | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3' UTR (PubMed:29547716). Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (By similarity).[UniProtKB/Swiss-Prot Function] |
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