Sdhaf4 (NM_026503) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR200347L4V

Lenti ORF particles, 1110058L19Rik (GFP-tagged) - Mouse RIKEN cDNA 1110058L19 gene (1110058L19Rik), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Mouse Tagged ORF Clone
• Tag: mGFP
• Symbol: Sdhaf4
• Synonyms: 1110058L19Rik; 1700001E18Rik; C6orf57
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-mGFP-P2A-Puro
• ACCN: NM_026503
• ORF Size: 315 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR200347).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_026503.1
• RefSeq Size: 675 bp
• RefSeq ORF: 315 bp
• Locus ID: 68002
• UniProt ID: Q8BTE0
• Cytogenetics: 1 A5
• Gene Summary: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer (By similarity).[UniProtKB/Swiss-Prot Function]