KIAA1199 (CEMIP) (NM_001293304) Human Untagged Clone

CAT#: SC338018

CEMIP (untagged) - Human cell migration inducing protein, hyaluronan binding (CEMIP), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CEMIP
• Synonyms: CCSP1; HYBID; KIAA1199; TMEM2L
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001293304, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGAGCTGCTGGGAGGCAGGACTTCCTCTTCAAGGCCATGCTGACCATCAGCTGGCTCACTCTGACCT
  GCTTCCCTGGGGCCACATCCACAGTGGCTGCTGGGTGCCCTGACCAGAGCCCTGAGTTGCAACCCTGGAA
  CCCTGGCCATGACCAAGACCACCATGTGCATATCGGCCAGGGCAAGACACTGCTGCTCACCTCTTCTGCC
  ACGGTCTATTCCATCCACATCTCAGAGGGAGGCAAGCTGGTCATTAAAGACCACGACGAGCCGATTGTTT
  TGCGAACCCGGCACATCCTGATTGACAACGGAGGAGAGCTGCATGCTGGGAGTGCCCTCTGCCCTTTCCA
  GGGCAATTTCACCATCATTTTGTATGGAAGGGCTGATGAAGGTATTCAGCCGGATCCTTACTATGGTCTG
  AAGTACATTGGGGTTGGTAAAGGAGGCGCTCTTGAGTTGCATGGACAGAAAAAGCTCTCCTGGACATTTC
  TGAACAAGACCCTTCACCCAGGTGGCATGGCAGAAGGAGGCTATTTTTTTGAAAGGAGCTGGGGCCACCG
  TGGAGTTATTGTTCATGTCATCGACCCCAAATCAGGCACAGTCATCCATTCTGACCGGTTTGACACCTAT
  AGATCCAAGAAAGAGAGTGAACGTCTGGTCCAGTATTTGAACGCGGTGCCCGATGGCAGGATCCTTTCTG
  TTGCAGTGAATGATGAAGGTTCTCGAAATCTGGATGACATGGCCAGGAAGGCGATGACCAAATTGGGAAG
  CAAACACTTCCTGCACCTTGGATTTAGACACCCTTGGAGTTTTCTAACTGTGAAAGGAAATCCATCATCT
  TCAGTGGAAGACCATATTGAATATCATGGACATCGAGGCTCTGCTGCTGCCCGGGTATTCAAATTGTTCC
  AGACAGAGCATGGCGAATATTTCAATGTTTCTTTGTCCAGTGAGTGGGTTCAAGACGTGGAGTGGACGGA
  GTGGTTCGATCATGATAAAGTATCTCAGACTAAAGGTGGGGAGAAAATTTCAGACCTCTGGAAAGCTCAC
  CCAGGAAAAATATGCAATCGTCCCATTGATATACAGGCCACTACAATGGATGGAGTTAACCTCAGCACCG
  AGGTTGTCTACAAAAAAGGCCAGGATTATAGGTTTGCTTGCTACGACCGGGGCAGAGCCTGCCGGAGCTA
  CCGTGTACGGTTCCTCTGTGGGAAGCCTGTGAGGCCCAAACTCACAGTCACCATTGACACCAATGTGAAC
  AGCACCATTCTGAACTTGGAGGATAATGTACAGTCATGGAAACCTGGAGATACCCTGGTCATTGCCAGTA
  CTGATTACTCCATGTACCAGGCAGAAGAGTTCCAGGTGCTTCCCTGCAGATCCTGCGCCCCCAACCAGGT
  CAAAGTGGCAGGGAAACCAATGTACCTGCACATCGGGGAGGAGATAGACGGCGTGGACATGCGGGCGGAG
  GTTGGGCTTCTGAGCCGGAACATCATAGTGATGGGGGAGATGGAGGACAAATGCTACCCCTACAGAAACC
  ACATCTGCAATTTCTTTGACTTCGATACCTTTGGGGGCCACATCAAGTTTGCTCTGGGATTTAAGGCAGC
  ACACTTGGAGGGCACGGAGCTGAAGCATATGGGACAGCAGCTGGTGGGTCAGTACCCGATTCACTTCCAC
  CTGGCCGGTGATGTAGACGAAAGGGGAGGTTATGACCCACCCACATACATCAGGGACCTCTCCATCCATC
  ATACATTCTCTCGCTGCGTCACAGTCCATGGCTCCAATGGCTTGTTGATCAAGGACGTTGTGGGCTATAA
  CTCTTTGGGCCACTGCTTCTTCACGGAAGATGGGCCGGAGGAACGCAACACTTTTGACCACTGTCTTGGC
  CTCCTTGTCAAGTCTGGAACCCTCCTCCCCTCGGACCGTGACAGCAAGATGTGCAAGATGATCACAGAGG
  ACTCCTACCCGGGGTACATCCCCAAGCCCAGGCAAGACTGCAATGCTGTGTCCACCTTCTGGATGGCCAA
  TCCCAACAACAACCTCATCAACTGTGCCGCTGCAGGATCTGAGGAAACTGGATTTTGGTTTATTTTTCAC
  CACGTACCAACGGGCCCCTCCGTGGGAATGTACTCCCCAGGTTATTCAGAGCACATTCCACTGGGAAAAT
  TCTATAACAACCGAGCACATTCCAACTACCGGGCTGGCATGATCATAGACAACGGAGTCAAAACCACCGA
  GGCCTCTGCCAAGGACAAGCGGCCGTTCCTCTCAATCATCTCTGCCAGATACAGCCCTCACCAGGACGCC
  GACCCGCTGAAGCCCCGGGAGCCGGCCATCATCAGACACTTCATTGCCTACAAGAACCAGGACCACGGGG
  CCTGGCTGCGCGGCGGGGATGTGTGGCTGGACAGCTGCCGGTTTGCTGACAATGGCATTGGCCTGACCCT
  GGCCAGTGGTGGAACCTTCCCGTATGACGACGGCTCCAAGCAAGAGATAAAGAACAGCTTGTTTGTTGGC
  GAGAGTGGCAACGTGGGGACGGAAATGATGGACAATAGGATCTGGGGCCCTGGCGGCTTGGACCATAGCG
  GAAGGACCCTCCCTATAGGCCAGAATTTTCCAATTAGAGGAATTCAGTTATATGATGGCCCCATCAACAT
  CCAAAACTGCACTTTCCGAAAGTTTGTGGCCCTGGAGGGCCGGCACACCAGCGCCCTGGCCTTCCGCCTG
  AATAATGCCTGGCAGAGCTGCCCCCATAACAACGTGACCGGCATTGCCTTTGAGGACGTTCCGATTACTT
  CCAGAGTGTTCTTCGGAGAGCCTGGGCCCTGGTTCAACCAGCTGGACATGGATGGGGATAAGACATCTGT
  GTTCCATGACGTCGACGGCTCCGTGTCCGAGTACCCTGGCTCCTACCTCACGAAGAATGACAACTGGCTG
  GTCCGGCACCCAGACTGCATCAATGTTCCCGACTGGAGAGGGGCCATTTGCAGTGGGTGCTATGCACAGA
  TGTACATTCAAGCCTACAAGACCAGTAACCTGCGAATGAAGATCATCAAGAATGACTTCCCCAGCCACCC
  TCTTTACCTGGAGGGGGCGCTCACCAGGAGCACCCATTACCAGCAATACCAACCGGTTGTCACCCTGCAG
  AAGGGCTACACCATCCACTGGGACCAGACGGCCCCCGCCGAACTCGCCATCTGGCTCATCAACTTCAACA
  AGGGCGACTGGATCCGAGTGGGGCTCTGCTACCCGCGAGGCACCACATTCTCCATCCTCTCGGATGTTCA
  CAATCGCCTGCTGAAGCAAACGTCCAAGACGGGCGTCTTCGTGAGGACCTTGCAGATGGACAAAGTGGAG
  CAGAGCTACCCTGGCAGGAGCCACTACTACTGGGACGAGGACTCAGGGCTGTTGTTCCTGAAGCTGAAAG
  CTCAGAACGAGAGAGAGAAGTTTGCTTTCTGCTCCATGAAAGGCTGTGAGAGGATAAAGATTAAAGCTCT
  GATTCCAAAGAACGCAGGCGTCAGTGACTGCACAGCCACAGCTTACCCCAAGTTCACCGAGAGGGCTGTC
  GTAGACGTGCCGATGCCCAAGAAGCTCTTTGGTTCTCAGCTGAAAACAAAGGACCATTTCTTGGAGGTGA
  AGATGGAGAGTTCCAAGCAGCACTTCTTCCACCTCTGGAACGACTTCGCTTACATTGAAGTGGATGGGAA
  GAAGTACCCCAGTTCGGAGGATGGCATCCAGGTGGTGGTGATTGACGGGAACCAAGGGCGCGTGGTGAGC
  CACACGAGCTTCAGGAACTCCATTCTGCAAGGCATACCATGGCAGCTTTTCAACTATGTGGCGACCATCC
  CTGACAATTCCATAGTGCTTATGGCATCAAAGGGAAGATACGTCTCCAGAGGCCCATGGACCAGAGTGCT
  GGAAAAGCTTGGGGCAGACAGGGGTCTCAAGTTGAAAGAGCAAATGGCATTCGTTGGCTTCAAAGGCAGC
  TTCCGGCCCATCTGGGTGACACTGGACACTGAGGATCACAAAGCCAAAATCTTCCAAGTTGTGCCCATCC
  CTGTGGTGAAGAAGAAGAAGTTGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001293304
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001293304.1, NP_001280233.1
• RefSeq Size: 7227 bp
• RefSeq ORF: 4086 bp
• Locus ID: 57214
• UniProt ID: Q8WUJ3
• Cytogenetics: 15q25.1
• Gene Summary: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.