NRG1 (NM_013961) Human Untagged Clone

CAT#: SC315410

NRG1 (untagged)-Human neuregulin 1 (NRG1), transcript variant GGF

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NRG1
• Synonyms: ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; NDF; SMDF
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_013961 edited
  GGGCTCGCGCGGAGGCCAGGAGCTGAGCGGCGGCGGCTGCCGGACGATGGGAGCGTGAGC
  AGGACGGTGATAACCTCTCCCCGATCGGGTTGCGAGGGCGCCGGGCAGAGGCCAGGACGC
  GAGCCGCCAGCGGCGGGACCCATCGACGACTTCCCGGGGCGACAGGAGCAGCCCCGAGAG
  CCAGGGCGAGCGCCCGTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCTCCCT
  GCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCC
  CCATCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCG
  CCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGC
  AGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCG
  GCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCAATTGAAAGAGATGAAAAGCCAGGAATCG
  GCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGA
  TTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAAACAAACCACAAAATATCAAG
  ATACAAAAAAAGCCAGGGAAGTCAGAACTTCGCATTAACAAAGCATCACTGGCTGATTCT
  GGAGAGTATATGTGCAAAGTGATCAGCAAATTAGGAAATGACAGTGCCTCTGCCAATATC
  ACCATCGTGGAATCAAACGAGATCATCACTGGTATGCCAGCCTCAACTGAAGGAGCATAT
  GTGTCTTCAGAGTCTCCCATTAGAATATCAGTATCCACAGAAGGAGCAAATACTTCTTCA
  TCTACATCTACATCCACCACTGGGACAAGCCATCTTGTAAAATGTGCGGAGAAGGAGAAA
  ACTTTCTGTGTGAATGGAGGGGAGTGCTTCATGGTGAAAGACCTTTCAAACCCCTCGAGA
  TACTTGTGCAAGTGCCCAAATGAGTTTACTGGTGATCGCTGCCAAAACTACGTAATGGCC
  AGCTTCTACAGTACGTCCACTCCCTTTCTGTCTCTGCCTGAATAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013961 unedited
  CCGCCCGTCGCGCAACGGGCGGTGGCGCGTACGGCGGGAGGCACATAGCAGAGCCCGCCT
  GCGAACGTCAGAACCCCGTATACGACCCACCACAGGGCGGCCGCGAACCCGGCACGAGGG
  GCCCGCGCGGAGGCCAGGAGCCGAGCGGCGGCGGCCGCCGGACGATGGGAGCGCGAGCAG
  GACGGTGACAACCCCCCCCCGACCGGGCCGCGAGGGCGCCGGGCAGAGGCCAGGACGCGA
  GCCGCCAGCGGCGGGACCCATCGACGACTTTCCCGGGGCGACAGGAGCAGCCCCGAGAGC
  CAGGGCGAGCGCCCGTTTCCAGGTGGCCGGACCGCCCGCCGCGTCCGCGCCGCGCCCCCT
  GCAGGCAACGGGAGACGCCCCCGCGCAGCGCGAGCGCCTCAGCGCGGCCGCTCGCTCTCC
  CCATCGAGGGACAAACTTTTCCCAAACCCGATCCGAGCCCTTGGACCAAACTCGCCTGCG
  CCGAGAGCCGTCCGCGTAGAGCGCTCCGTCTCCGGCGAGATGTCCGAGCGCAAAGAAGGC
  AGAGGCAAAGGGAAGGGCAAGAAGAAGGAGCGAGGCTCCGGCAAGAAGCCGGAGTCCGCG
  GCGGGCAGCCAGAGCCCAGCCTTGCCTCCCCAATTGAAAGAGATGAAAAGCCAGGAATCG
  GCTGCAGGTTCCAAACTAGTCCTTCGGTGTGAAACCAGTTCTGAATACTCCTCTCTCAGA
  TTCAAGTGGTTCAAGAATGGGAATGAATTGAATCGAAAAACAACCACAAATATCAAGATA
  CAAAAAAGCCAGGGAAGTCAGACTTCGCATTAACAAAGCATCACTGGCTGATTCTGGAGA
  GTATATGTGCAAAGGTGATCAGCAATTAGGAAATGACAGTGCCTCTGCCCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_013961 unedited
  TGGTGCTGCACTTCAGGGCCGGAGAGGCACCTGGGGAGGGGTCACAGGGATGCCACCCGG
  GATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGACTATTCAGGCAGAGACAG
  AAAGGGAGTGGACGTACTGTAGAAGCTGGCCATTACGTAGTTTTGGCAGCGATCACCAGT
  AAACTCATTTGGGCACTTGCACAAGTATCTCGAGGGGTTTGAAAGGTCTTTCACCATGAA
  GCACTCCCCTCCATTCACACAGAAAGTTTTCTCCTTCTCCGCACATTTTACAAGATGGCT
  TGTCCCAGTGGTGGATGTAGATGTAGATGAAGAAGTATTTGCTCCTTCTGTGGATACTGA
  TATTCTAATGGGAGACTCTGAAGACACATATGCTCCTTCAGTTGAGGCTGGCATACCAGT
  GATGATCTCGTTTGATTCCACGATGGTGATATTGGCAGAGGCACTGTCATTTCCTAATTT
  GCTGATCACTTTGCACATATACTCTCCAGAATCAGCCAGTGATGCTTTGTTAATGCGAAG
  TTCTGACTTCCCTGGCTTTTTTTGTATCTTGATATTTTGTGGTTTGTTTTTTCGATTCAA
  TTCATTCCCATTCTTGAACCACTTGAATCTGAGAGAGGAGTATTCAGAACTGGTTTCACA
  CCGAAGGACTAGTTTGGAACCTGCAGCCGATTCCTGGCTTTTCATCTCTTTCAATTGGGG
  AGGCAAGGCTGGGCTCTGGCTGCCCGCCGCGGACTCCGGCTTCTTGCCGGAGCCTCGCTC
  CTTCTTCTTGCCCTTCCCTTTGCCTCTGCCTTCTTTGCGCTCGGACATCTCGCCGGAGAC
  GGAGCGCTCTACGCGGACGCTCTCGGCGCAGCGAGTTTGGTCCAAGGGCTCGGATCGGGT
  TTGGGAAAGTTTGTCCTCGATGGGGAGAGCGAGCGCCGCGCTGAGCGCTCGCGCTGCGCG
  GGGGGCGTCTCCGTTGCCTGCAGGAGCGCCGCCGCGAAGCG
  
• Restriction Sites: Please inquire
• ACCN: NM_013961
• Insert Size: 1100 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_013961.2, NP_039255.1
• RefSeq Size: 1703 bp
• RefSeq ORF: 726 bp
• Locus ID: 3084
• Cytogenetics: 8p12
• Domains: ig, IGc2, IG, EGF, EGF
• Protein Families: Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
• Protein Pathways: ErbB signaling pathway
• Gene Summary: The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
  Transcript Variant: The GGF (also called GGFHFB1) variant is identical to HRG-beta3 variant, except for its shorter 5' and 3' UTRs. The GGF and GGF2 variants are expressed in the nervous system and function as a neuronal signal that promotes the proliferation and survival of the oligodendrocyte and the myelinating cells.