CCR3 (NM_001837) Human Untagged Clone

CAT#: SC118980

CCR3 (untagged)-Human chemokine (C-C motif) receptor 3 (CCR3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CCR3
• Synonyms: CC-CKR-3; C C CKR3; CD193; CKR 3; CKR3; CMKBR3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001837, RT-PCR generated
  ATGACAACCTCACTAGATACAGTTGAGACCTTTGGTACCACATCCTACTATGATGACGTG
  GGCCTGCTCTGTGAAAAAGCTGATACCAGAGCACTGATGGCCCAGTTTGTGCCCCCGCTG
  TACTCCCTGGTGTTCACTGTGGGCCTCTTGGGCAATGTGGTGGTGGTGATGATCCTCATA
  AAATACAGGAGGCTCCGAATTATGACCAACATCTACCTGCTCAACCTGGCCATTTCGGAC
  CTGCTCTTCCTCGTCACCCTTCCATTCTGGATCCACTATGTCAGGGGGCATAACTGGGTT
  TTTGGCCATGGCATGTGTAAGCTCCTCTCAGGGTTTTATCACACAGGCTTGTACAGCGAG
  ATCTTTTTCATAATCCTGCTGACAATCGACAGGTACCTGGCCATTGTCCATGCTGTGTTT
  GCCCTTCGAGCCCGGACTGTCACTTTTGGTGTCATCACCAGCATCGTCACCTGGGGCCTG
  GCAGTGCTAGCAGCTCTTCCTGAATTTATCTTCTATGAGACTGAAGAGTTGTTTGAAGAG
  ACTCTTTGCAGTGCTCTTTACCCAGAGGATACAGTATATAGCTGGAGGCATTTCCACACT
  CTGAGAATGACCATCTTCTGTCTCGTTCTCCCTCTGCTCGTTATGGCCATCTGCTACACA
  GGAATCATCAAAACGCTGCTGAGGTGCCCCAGTAAAAAAAAGTACAAGGCCATCCGGCTC
  ATTTTTGTCATCATGGCGGTGTTTTTCATTTTCTGGACACCCTACAATGTGGCTATCCTT
  CTCTCTTCCTATCAATCCATCTTATTTGGAAATGACTGTGAGCGGAGCAAGCATCTGGAC
  CTGGTCATGCTGGTGACAGAGGTGATCGCCTACTCCCACTGCTGCATGAACCCGGTGATC
  TACGCCTTTGTTGGAGAGAGGTTCCGGAAGTACCTGCGCCACTTCTTCCACAGGCACTTG
  CTCATGCACCTGGGCAGATACATCCCATTCCTTCCTAGTGAGAAGCTGGAAAGAACCAGC
  TCTGTCTCTCCATCCACAGCAGAGCCGGAACTCTCTATTGTGTTTTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001837 unedited
  TTTTAGTTGGGTTGGGNNGCTTANNCGATGGCGTTTAGGGCTTTGACGTGAATCTGCAGA
  AATCGGCTTGAGAAGTGAAATGACACACCCACTAGATACAGTTGAGACCTTTGGTACCAC
  ATCCTACTATGATGACGTGGGCCTGCTCTGTGAAAAAGCTGATACCAGAGCACTGATGGC
  CCAGTTTGTGCCCCCGCTGTACTCCCTGTAGTCATTGTGGGCCTCTTGGGCAATGTGGTG
  GTGGTGATGATCCTCATAAAATACAGGAGGCTCCGAATTATGACCAACATCTACCTGCTC
  AACCTGGCCATTTCGGACCTGCTCTTCCTCGTCACCCTTCCATTCTGGATCCACTATGTC
  AGGGGGCATAACTGGGTTTTTGGCCATGGCATGTGTAAGCTCCTCTCAGGGTTTTATCAC
  ACAGGCTTGTACAGCGAGATCTTTTTCATAATCCTGCTGACAATCGACAGGTACCTGGCC
  ATTGTCCATGCTGTGTTTGCCCTTCGAGCCCGGACTGTCACTTTTGGTGTCATCACCAGC
  ATCGTCACCTGNGGCCTGACAGTGCTAGCAGCTCTTCCTGAATTTATCTTCTATGAGACT
  GAACAGTTGTTTGAAGAGACTCTTTGCAGTGCTCTTTACCCAGACGATACAGTATATAGC
  TGGGAGCATTTNCACACTCTGAGGATGACCATCTTCTGTCTCCGTCTCCCTCTGCTCGTT
  ATGGCCATCTGCTACACAGGATCATCAAAACGCTGCTGAAGTGCCCCAGTAAAAAAAAAT
  ACAAGGCCATCCCGGCTCATTTTTGTCATCATGGCCGGGGTTTATTCATTTTCTGGAAAC
  CCTTAAAAGGTGGGCTATTCCTTCTCTCTTGCTAATAATCCATCTTATTTGGAAAGACTG
  TGAGCGGAGAAGGAACTGAACTGGAAAGCCGGGGAAN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001837 unedited
  GAAAGCCCATTGGNGATGGCAACTTCCAGGACCAGNAAAGCACTGGGGNAGGGTCACAGG
  AATGCCACCCGGGTTCTGTTCAGGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGACA
  AGCTTGATATCGGTACCGAGCTCGGATCCACTAGTAACGGCCGCCAGTGTGCTGGAATTC
  GGCTTCTGACCTAAAACACAATAGAGAGTTCCGGCTCTGCTGTGGATGGAGAGACAGAGA
  TGGTTCTTTCAAGCTTCTCACTAGGAAGGAATGGGACGTAACTGCCCAGGTGCAAGAGCA
  AGTGCCTGTGGAAGAAGTGGCACCGGTACTTCCGGAACCTCTCTCCAACCACAGCGTAAA
  TGACCCGGATCATGCACCCAAAGGGAGAAGGCAATCATATATATCGCCGCCGGGAACCGA
  TACAAATGCTTAAAACCTTTCGGGAATTGGCTATGTTATGTGGAGTGATGATGAAAATAG
  CAGCATATCCATAAGAGAAAACCGGTATCTGCGTGTGTTTTTATTAGGGAGAAGGAAAAA
  TATACGAATTATGCGGGCGGGGGGGCGGGAAAGAAATATTTCGAGTTTTGAGGGATGCGG
  TGTTTTAAAAAAAAGGGCGGGCGATGGAAAGGGTATTTTTTTTTTCGAAAACTCTCCCGC
  CAAAACCTCCTCTTTTATCAGACGAAATAAGGGGTAATAGAATGAAGGAAGAATGACGCG
  AGGGTGTAAGCCGCGCCGGAAAAGGCCGGGGCGCTTAAGTTTCTTTAGATTATTTAAAGA
  TTTTTCCCCCGCTACATAGAAGTATAGCCCCTCCTATAAAAAAACATACCCGCGCGCGGC
  GAAGCGGCGGAAATAAACCAAAAAAAAAACGGGCCGGAAAAAATCGCTTGATATCGTGTG
  CGGAGGTT
  
• Restriction Sites: Please inquire
• ACCN: NM_001837
• Insert Size: 1200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001837.2, NP_001828.1
• RefSeq Size: 1945 bp
• RefSeq ORF: 1068 bp
• Locus ID: 1232
• UniProt ID: P51677
• Cytogenetics: 3p21.31
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (1) represents the longest transcript. It encodes the same isoform (1) as variant 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.