IL18R Beta (IL18RAP) (NM_003853) Human Untagged Clone

CAT#: SC117717

IL18RAP (untagged)-Human interleukin 18 receptor accessory protein (IL18RAP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL18R Beta
• Synonyms: ACPL; CD218b; CDw218b; IL-1R-7; IL-1R7; IL-1RAcPL; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL18RB
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117717 sequence for NM_003853 edited (data generated by NextGen Sequencing)
  ATGCTCTGTTTGGGCTGGATATTTCTTTGGCTTGTTGCAGGAGAGCGAATTAAAGGATTT
  AATATTTCAGGTTGTTCCACAAAAAAACTCCTTTGGACATATTCTACAAGGAGTGAAGAG
  GAATTTGTCTTATTTTGTGATTTACCAGAGCCACAGAAATCACATTTCTGCCACAGAAAT
  CGACTCTCACCAAAACAAGTCCCTGAGCACCTGCCCTTCATGGGTAGTAACGACCTATCT
  GATGTCCAATGGTACCAACAACCTTCGAATGGAGATCCATTAGAGGACATTAGGAAAAGC
  TATCCTCACATCATTCAGGACAAATGTACCCTTCACTTTTTGACCCCAGGGGTGAATAAT
  TCTGGGTCATATATTTGTAGACCCAAGATGATTAAGAGCCCCTATGATGTAGCCTGTTGT
  GTCAAGATGATTTTAGAAGTTAAGCCCCAGACAAATGCATCCTGTGAGTATTCCGCATCA
  CATAAGCAAGACCTACTTCTTGGGAGCACTGGCTCTATTTCTTGCCCCAGTCTCAGCTGC
  CAAAGTGATGCACAAAGTCCAGCGGTAACCTGGTACAAGAATGGAAAACTCCTCTCTGTG
  GAAAGGAGCAACCGAATCGTAGTGGATGAAGTTTATGACTATCACCAGGGCACATATGTA
  TGTGATTACACTCAGTCGGATACTGTGAGTTCGTGGACAGTCAGAGCTGTTGTTCAAGTG
  AGAACCATTGTGGGAGACACTAAACTCAAACCAGATATTCTGGATCCTGTCGAGGACACA
  CTGGAAGTAGAACTTGGAAAGCCTTTAACTATTAGCTGCAAAGCACGATTTGGCTTTGAA
  AGGGTCTTTAACCCTGTCATAAAATGGTACATCAAAGATTCTGACCTAGAGTGGGAAGTC
  TCAGTACCTGAGGCGAAAAGTATTAAATCCACTTTAAAGGATGAAATCATTGAGCGTAAT
  ATCATCTTGGAAAAAGTCACTCAGCGTGATCTTCGCAGGAAGTTTGTTTGCTTTGTCCAG
  AACTCCATTGGAAACACAACCCAGTCCGTCCAACTGAAAGAAAAGAGAGGAGTGGTGCTC
  CTGTACATCCTGCTTGGCACCATCGGGACCCTGGTGGCCGTGCTGGCGGCGAGTGCCCTC
  CTCTACAGGCACTGGATTGAAATAGTGCTGCTGTACCGGACCTACCAGAGCAAGGATCAG
  ACGCTTGGGGATAAAAAGGATTTTGATGCTTTCGTATCCTATGCAAAATGGAGCTCTTTT
  CCAAGTGAGGCCACTTCATCTCTGAGTGAAGAACACTTGGCCCTGAGCCTATTTCCTGAT
  GTTTTAGAAAACAAATATGGATATAGCCTGTGTTTGCTTGAAAGAGATGTGGCTCCAGGA
  GGAGTGTATGCAGAAGACATTGTGAGCATTATTAAGAGAAGCAGAAGAGGAATATTTATC
  TTGAGCCCCAACTATGTCAATGGACCCAGTATCTTTGAACTACAAGCAGCAGTGAATCTT
  GCCTTGGATGATCAAACACTGAAACTCATTTTAATTAAGTTCTGTTACTTCCAAGAGCCA
  GAGTCTCTACCTCATCTCGTGAAAAAAGCTCTCAGGGTTTTGCCCACAGTTACTTGGAGA
  GGCTTAAAATCAGTTCCTCCCAATTCTAGGTTCTGGGCCAAAATGCGCTACCACATGCCT
  GTGAAAAACTCTCAGGGATTCACGTGGAACCAGCTCAGAATTACCTCTAGGATTTTTCAG
  TGGAAAGGACTCAGTAGAACAGAAACCACTGGGAGGAGCTCCCAGCCTAAGGAATGGTGA
  
  Clone variation with respect to NM_003853.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003853 unedited
  GCATTTGTATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGAAAGAGTATCTC
  TCTGGATAGGAAGAAATATAGTAGAACCCTTTGAAAATGGATATTTTCACATATTTTCGT
  TCAGATACAAAAGCTGGCAGTTACTGAAATAAGGACTTGAAGTTCCTTCCTCTTTTTTTT
  ATGTCTTAAGAGCAGGAAATAAAGAGACAGCTGAAGGTGTAGCCTTGACCAACTGAAAGG
  GAAATCTTCATCCTCTGAAAAAACATATGTGATTCTCAAAAAACGCATCTGGAAAATTGA
  TAAAGAAGCGATTCTGTAGATTCTCCCAGCGCTGTTGGGCTCTCAATTCCTTCTGTGAAG
  GACAACATATGGTGATGGGGAAATCAGAAGCTTTGAGACCCTCTACACCTGGATATGAAT
  CCCCCTTCTAATACTTACCAGAAATGAAGGGGATACTCAGGGCAGAGTTCTGAATCTCAA
  AACACTCTAATCTGGCAAAGGAATGAAGTTATTGGAGTGATGACAGGAACACGGGAGAAC
  AATGCTCTGTTTGGGCTGGATATTTCTTTGGCTTGTTGCAGGAGAGCGAATTAAAGGATT
  TAATATTTCAGGTTGTTCCACAAAAAAACTCCTTTGGACATATTCTACAAGGAGTGAAGA
  GGAATTTGTCTTATTTTGTGATTTACCAGAGCCACAGAAATCACATTTCTGCCACAGAAA
  TCGACTCTCACCAAAACAAGTCCCTGAGCACCTGCCCTTCATGGGTAGTAACGACCTATC
  TGATGTCCAATGGTACCAACACCTTTCGATGGAGATCCATTAGAGGACATTANGAAAAGC
  TATCCTCACATCATTCAGGACAATGTACCCTTACTTNTTGACCCAGGNTGAATANTCCTG
  GGTATATATTTGTAGACCAAGAGATTAGAGCCCTATGAGTACCTGTGTGTCAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003853 unedited
  GCGGCCGCAATTTANAGTCGAGTTTTTTTTTTTTTTTTTTAATAAAATAATATTTATTTG
  ATTGCAAGTATACATAAAGTCATATGTACAATACATGGTAGACATGACAGTTCCCTAGCC
  ATAAGGCAGAAGTAGCTGTATTTTCTGATTCTGCTCGGACCACTGGGAAATCTTAGGGGT
  GTTGTGTACTGAAAGTACCCAAGGTCTAGAGAATTCACTCGCCGTCTGTCCAGTCCAGGA
  AATCAAAGGCTCTAAACCACAGTCTCAATCCCATTCCATTGTCCATCAAGCTTGCTTGGT
  GCTGGCAGGAGACTCTTTGAATTTCCTATCAGCCTGAACACACACACACAGAGCTGTGAG
  TTCTGTCCAGCAACATCTCTATCCCAGGGACTGGACTGGAGGGGGCTCCAGGGCTCATTT
  CACCATTCCTTAGGCTGGGAGCTCCTCCCAGTGGTTTCTGTTCTACTGAGTCCTTTCCAC
  TGAAAAATCCTAGAGGTAATTCTGAGCTGGTTCCACGTGAATCCCTGAGAGTTTTTCACA
  GGCATGTGGTAGCGCATTTTGGCCCACACCTACAATTGGAGGAACTGATTTTAAGCCTCT
  CCAAGTAACTGTGGGCAAAACCCTGAGAGCTTTTTTCACGAGATGAGGTANAGACTCTGG
  CTCTTGGAAGTAACACACCTTAATTAAACGAGCTTCACCGTTTGATCCTCCAAGGCAAGA
  TTCCCTGCTGCTTGTACTTCAAAAAACTTGGGCCCATGCCATTATTGGCGGGCCTAAGAA
  CAAAATCCCCTTTTCGCCTCCCTTAAAACGCCTCCCAAGGTCTTCTGCAACCACCTCTCC
  CGGAGCACCTTCTTTTAAAGAAACCACAGCTATACCATTTTGGTTTCTTAACACTAGAAA
  AAGCCCCGCGCCCATGTTTTTCATTTAAAATAAAAGGCCCCCACCTCGGAACAAGTCCAA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003853
• Insert Size: 2850 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003853.2, NP_003844.1
• RefSeq Size: 2668 bp
• RefSeq ORF: 1800 bp
• Locus ID: 8807
• UniProt ID: O95256
• Cytogenetics: 2q12.1
• Domains: TIR, IG
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction
• Gene Summary: The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]