ILRUN (NM_022758) Human Untagged Clone

CAT#: SC112447

C6orf106 (untagged)-Human chromosome 6 open reading frame 106 (C6orf106), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ILRUN
• Synonyms: C6orf106; dJ391O22.4; FP852
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022758, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGGGCATGGACGTAGACCTGGACCCGGAGCTGATGCAGAAGTTCAGCTGCCTGGGCACCACCGACA
  AGGACGTGCTCATCTCCGAGTTCCAGAGGCTGCTCGGCTTCCAGCTCAATCCTGCCGGTTGCGCCTTCTT
  CCTGGACATGACCAACTGGAACCTACAAGCAGCAATTGGCGCCTATTATGACTTTGAGAGCCCAAACATC
  AGTGTGCCCTCTATGTCCTTTGTTGAAGATGTCACCATAGGAGAAGGGGAGTCAATACCTCCGGATACTC
  AGTTTGTAAAAACATGGCGGATCCAGAATTCTGATGTCATCTGGGTGATTCTCAGTGTGGAGGTGGGTGG
  ACTTTTAGGAGTAACGCAGCAGCTGTCATCTTTTGAAACGGAGTTCAACACACAGCCGCATCGTAAGGTA
  GAAGGAAACTTCAACCCTTTTGCCTCTCCCCAAAAGAACCGACAATCAGATGAAAACAACTTAAAAGACC
  CTGGGGGCTCCGAGTTCGACTCGATCAGCAAAAACACATGGGCTCCTGCTCCTGACACATGGGCTCCTGC
  TCCTGACCAAACTGAGCAAGACCAGAATAGACTGTCACAGAACTCTGTAAATCTGTCTCCCAGCAGTCAC
  GCAAACAACTTATCAGTAGTGACTTACAGTAAGGGGCTCCATGGGCCTTACCCCTTCGGCCAGTCTTAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022758 unedited
  GTGCACCATTTTGTAATACGAACTCACTATAGGGCGGCCGCGATTCGGCACGAGGGANAA
  AAGCTTGTGTGAAATTCCCTCTTCACCTCCCCACCCCCCAAAAAATAAAAGGGGGCATAA
  ACTTTATTCCACTGGAGAAGCCCTGGGGGTGGCTGGAGCCAGCCTGCTGAGAAGCGTGGT
  GCAGCTGGGTCTGGGACTTCACTAGAGCTTACTCTGGAGCACCTATTTTCTGTGCACATG
  GGAGTGCTCCACTCCCTAGCAGAGCAGAGGGAAGTCTCTGCCAGGTACCCACGCCACAGG
  CCTCAGGATGGCTTTTTGTCTGAGGGCCTCATTAGGCCCAGACTGCTGCTGCTGGTACCA
  GTCTCCTGAGACACTGCCTCCCTGGAGCCCATGCATGCCCAGCTGTTCTTACTGCTTAGT
  AGCCTTGAAGCAGCACATCTCCACTGTCCCTGGCAGGATTGTGGGAGGCTTCACAACCCC
  TGCTTTCCTGACTTCCTCTTCTGCCCAACACTGGGTGCCCCTTCCCAGTTTCCCAGCAGG
  GGCTTCATGGGCCACCGTCAGTGGGTCTGGGCCTGCCAGAGTCGTCTTGCTCTTCCTCTT
  GCTTCTAGGCAACCACACTTGGCAAGTTAAATGTCCCAAGCACCTTGTCTCCCTTCCCAA
  GAACAAACCATTTCTGTGCACATCCTTGGNAGCGAGATGAGCTCCTTGCAGAGGGCCAGA
  TAAGTGCAAGTCATGGAGTGCACGCAGAGGGGTCCATGGCTTTCCCCACCCAGGGAGGGN
  ATCAGTATCATTCATTCTCTCTCCCCTCACTGGTATGGGTTCANAAGCATGCCTAAGGCC
  CCTCTCTGCTCCCCTGNCTANTGGGGTGGGAGGGCCTACCTCTCAACCCCATAAGCCCCG
  GTTCCTTTTAGAATCCTCACCCAATGGCAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_022758 unedited
  GGCTCTGCGTGTTGATATTATCCTACAAATTTNATTTATACAATAAGGGAAAAACCTCCT
  CATCTTTATCTCCTCCTAGGCACCATGAGGCCCCACCACAAACATCCAGCTGGCTTTCTA
  CACACACCACTGTCCAGGTGGGAAGGGCAGCCACTGCTGCTCCTGCATTCACCCAAGGAA
  ACAAAGGAAAGGTGCGGCGAGGCAGGGTGGGGTGAGTAATCAGCTTGCACTTCTGAGCCC
  TGGCAACCCTACCATCCTCTCCTGCTGGGCTCAGATTGAATTTGGGGAGGTATTTATTCT
  CATGCCCATTTCCCACCATGGCCACCCTCAGGCCACACCAGCTGTTTGGTGAGGTTCTCT
  CCAGGCTGGAAGTAACTTTGATGGGCTTAAGGTTACAGCCAGTCCTTATGGGGGAGAGAA
  GGCTGACTGCTTCTTGTAGAAAAATGCCCCAAATTCAACTGTCCTCACGGCAAAAAGAAA
  AAAAGCATGCACACGTGCACATCCATCCACACACACACACCTCACTCCATGCACACTGAC
  AGATTCTTCCCAAGTCTGAACCCCTCTGTCTCCCCAACTGGGTTCAGACCCTATCACCTA
  ACCATGGTGTCTGCCTCACCTCCTGAGCGCCAGACGCAGGTGGTCCTGCCCAGAGGTGGC
  CTGCCACTTGGTGAAGATTCTAAGAGGAGCAGGGACTATTGGGGCTGAAAAGTACCCACT
  ACCACCCCACTAAGCAGGGGAACAGATAGGGGCCCTTAGCATTGTTCTGAACCCTACCCA
  TGAAGGGAGAGAGATGAATGATCCTGTACCCTCCCTGGGCTGGGGAAGCCTGGACCCCTT
  TGCTGCACTCCATGATTGCCCTTACTTTGGCCCTCTGAAGGAGCTATTCCGCCCTCCAAG
  ATCGCCCAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_022758
• Insert Size: 1620 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_022758.3, NP_073595.1
• RefSeq Size: 4235 bp
• RefSeq ORF: 393 bp
• Locus ID: 64771
• UniProt ID: Q9H6K1
• Cytogenetics: 6p21.31
• Gene Summary: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.