TAB2 (NM_015093) Human Untagged Clone

CAT#: SC111198

TAB2 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TAB2
• Synonyms: CHTD2; MAP3K7IP2; TAB-2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_015093, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGTAC
  CTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTC
  TCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGT
  CTACGCAATCACATGACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAG
  GAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTC
  CAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTT
  GGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAA
  CATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGAC
  TGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGA
  AATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTG
  GCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGAC
  TACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACC
  TCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCT
  CACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGA
  AATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGC
  ACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCC
  CAAATACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGA
  TGAACAGGTCATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG
  AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAG
  GCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTAC
  AGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTT
  CTTAATCATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATG
  TGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTT
  GGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAA
  TTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATAT
  CCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGA
  CTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAAC
  TTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAA
  CACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAA
  CCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015093 unedited
  NGGGTCGAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACCAGGATGGCCCA
  AGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGT
  ACCTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTG
  TGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTC
  AGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAACTTGGACTTGCA
  ATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCT
  AACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCA
  GCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTTGGAATGTC
  CAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGG
  AACATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCC
  AAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACC
  TGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACAACTCCTGG
  TGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATGAA
  CCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCTGCATCTAA
  TNCTCTGTCACATACCTCATCTCACAGCCAAATCAGCAGGGCCCCAGACCTCTCATGTCT
  ACTGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_015093 unedited
  NAATACTCTGNNACCGCGNNCCGCATTCTAGNGATCGAGTTTTTTTTTTTTTTTTTTTTT
  CAAAATATCCAAATTACGTTTTATTAATAAAACAAGTAAAAACTGATTTATCAATCTTCA
  CATAAAACTGCAGATGAAGCTGAAAAACAAGGCCTATTTTAAAAATAAATTGCATCAAAC
  GTAAGGGCTTTGGGTCTATGGTTTAATTACCTAGGATTGTCATATTTCTTCCCATATACA
  AAATGCAAAGCCTGAAAGTTAGGGCTCTGACATTCATAGAGATCAACTGTAATAATCCCA
  TTTAAAACACAGCCACTTGCAAACATTTACAGGGGGTGGTAGTCTATATTATCTTCCATC
  CTTTGCTCTATTTCAGCACTTCCCTTAGCCCCATTCTAAGCACTCATATAATTTCATAAT
  TCTGCCTTTTTAAATGCATACTGTTCTTTTTCTTGATTTCAGTTATATACCTTCCTGATC
  ATCTGAATATTTTCCTTACAAAAATATTTTATCAAAATAAAGAGATGCTTGAGGTTGCTT
  CCATGTTCAAGTTCGCTCGGTCTTTTTTTCACGCTTCCCTCCATCTTGTTTAATACGCCA
  GCCCTTGCCTTATAAATCCCTTTATCCTGTCCCCCCCCCTCGTTCATTATTGCCTTCCCC
  TCCCCATAACTCTCTTAAACTTCTTCTCCCATACTCCGGTCCCCTTTCTCCCTCCTTCTT
  TTCGCTCTTAACCCCGTATCTATCTATAATCCCCCGCTCCTCTTTCCCCCCCTCCCATTA
  TCCACACCACATTCTATATCTTCCCCTTTCCCTATCCTATTTTCCCTCCTTCTTCTTTTT
  CCCTCCTTTTTTCCCCCTCCTCTTTCCTCTTCATTTTCTTAAATCCTTTTCTTTTCCCTC
  CCTCCTCTTCTTCTGTTTTCTCCCCCATTTCTCGACCCTCTCCTCCTCCCCCACCTCTTC
  CCACC
  
• Restriction Sites: ECoRI-NOT
• ACCN: NM_015093
• Insert Size: 3670 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_015093.2, NP_055908.1
• RefSeq Size: 4149 bp
• RefSeq ORF: 2082 bp
• Locus ID: 23118
• UniProt ID: Q9NYJ8
• Cytogenetics: 6q25.1
• Domains: zf-RanBP, CUE
• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode isoform a.