CACNA1H (NM_001005407) Human Tagged ORF Clone

CAT#: RG218260

CACNA1H (tGFP-tagged) - Human calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H), transcript variant 2

Product Images

Circular map for RG218260

Specifications

Product Data

• Type: Human Tagged ORF Clone
• Tag: TurboGFP
• Symbol: CACNA1H
• Synonyms: CACNA1HB; Cav3.2; ECA6; EIG6; HALD4
• Vector: pCMV6-AC-GFP
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  ORF Nucleotide Sequence

  >RG218260 representing NM_001005407
  Red=Cloning site Blue=ORF Green=Tags(s)
  
  GCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCGCGCCAGATCTC
  AAGCTTAACTAGCTAGCGGACCGAC
  
  ATGACCGAGGGCGCACGGGCCGCCGACGAGGTCCGGGTGCCCCTGGGCGCGCCGCCCCCTGGCCCTGCGG
  CGTTGGTGGGGGCGTCCCCGGAGAGCCCCGGGGCGCCGGGACGCGAGGCGGAGCGGGGGTCCGAGCTCGG
  CGTGTCACCCTCCGAGAGCCCGGCGGCCGAGCGCGGCGCGGAGCTGGGTGCCGACGAGGAGCAGCGCGTC
  CCGTACCCGGCCTTGGCGGCCACGGTCTTCTTCTGCCTCGGTCAGACCACGCGGCCGCGCAGCTGGTGCC
  TCCGGCTGGTCTGCAACCCATGGTTCGAGCACGTGAGCATGCTGGTAATCATGCTCAACTGCGTGACCCT
  GGGCATGTTCCGGCCCTGTGAGGACGTTGAGTGCGGCTCCGAGCGCTGCAACATCCTGGAGGCCTTTGAC
  GCCTTCATTTTCGCCTTTTTTGCGGTGGAGATGGTCATCAAGATGGTGGCCTTGGGGCTGTTCGGGCAGA
  AGTGTTACCTGGGTGACACGTGGAACAGGCTGGATTTCTTCATCGTCGTGGCGGGCATGATGGAGTACTC
  GTTGGACGGACACAACGTGAGCCTCTCGGCTATCAGGACCGTGCGGGTGCTGCGGCCCCTCCGCGCCATC
  AACCGCGTGCCTAGCATGCGGATCCTGGTCACTCTGCTGCTGGATACGCTGCCCATGCTCGGGAACGTCC
  TTCTGCTGTGCTTCTTCGTCTTCTTCATTTTCGGCATCGTTGGCGTCCAGCTCTGGGCTGGCCTCCTGCG
  GAACCGCTGCTTCCTGGACAGTGCCTTTGTCAGGAACAACAACCTGACCTTCCTGCGGCCGTACTACCAG
  ACGGAGGAGGGCGAGGAGAACCCGTTCATCTGCTCCTCACGCCGAGACAACGGCATGCAGAAGTGCTCGC
  ACATCCCCGGCCGCCGCGAGCTGCGCATGCCCTGCACCCTGGGCTGGGAGGCCTACACGCAGCCGCAGGC
  CGAGGGGGTGGGCGCTGCACGCAACGCCTGCATCAACTGGAACCAGTACTACAACGTGTGCCGCTCGGGT
  GACTCCAACCCCCACAACGGTGCCATCAACTTCGACAACATCGGCTACGCCTGGATTGCCATCTTCCAGG
  TGATCACGCTGGAAGGCTGGGTGGACATCATGTACTACGTCATGGACGCCCACTCATTCTACAACTTCAT
  CTATTTCATCCTGCTCATCATCGTGGGCTCCTTCTTCATGATCAACCTGTGCCTGGTGGTGATTGCCACG
  CAGTTCTCGGAGACGAAGCAGCGGGAGAGTCAGCTGATGCGGGAGCAGCGGGCACGCCACCTGTCCAACG
  ACAGCACGCTGGCCAGCTTCTCCGAGCCTGGCAGCTGCTACGAAGAGCTGCTGAAGTACGTGGGCCACAT
  ATTCCGCAAGGTCAAGCGGCGCAGCTTGCGCCTCTACGCCCGCTGGCAGAGCCGCTGGCGCAAGAAGGTG
  GACCCCAGTGCTGTGCAAGGCCAGGGTCCCGGGCACCGCCAGCGCCGGGCAGGCAGGCACACAGCCTCGG
  TGCACCACCTGGTCTACCACCACCATCACCACCACCACCACCACTACCATTTCAGCCATGGCAGCCCCCG
  CAGGCCCGGCCCCGAGCCAGGCGCCTGCGACACCAGGCTGGTCCGAGCTGGCGCGCCCCCCTCGCCACCT
  TCCCCAGGCCGCGGACCCCCCGACGCAGAGTCTGTGCACAGCATCTACCATGCCGACTGCCACATAGAGG
  GGCCGCAGGAGAGGGCCCGGGTGGCACATGCCGCAGCCACTGCCGCTGCCAGCCTCAGACTGGCCACAGG
  GCTGGGCACCATGAACTACCCCACGATCCTGCCCTCAGGGGTGGGCAGCGGCAAAGGCAGCACCAGCCCC
  GGACCCAAGGGGAAGTGGGCCGGTGGACCGCCAGGCACCGGGGGGCACGGCCCGTTGAGCTTGAACAGCC
  CTGATCCCTACGAGAAGATCCCGCATGTGGTCGGGGAGCATGGACTGGGCCAGGCCCCTGGCCATCTGTC
  GGGCCTCAGTGTGCCCTGCCCCCTGCCCAGCCCCCCAGCGGGCACACTGACCTGTGAGCTGAAGAGCTGC
  CCGTACTGCACCCGTGCCCTGGAGGACCCGGAGGGTGAGCTCAGCGGCTCGGAAAGTGGAGACTCAGATG
  GCCGTGGCGTCTATGAATTCACGCAGGACGTCCGGCACGGTGACCGCTGGGACCCCACGCGACCACCCCG
  TGCGACGGACACACCAGGCCCAGGCCCAGGCAGCCCCCAGCGGCGGGCACAGCAGAGGGCAGCCCCGGGC
  GAGCCAGGCTGGATGGGCCGCCTCTGGGTTACCTTCAGCGGCAAGCTGCGCCGCATCGTGGACAGCAAGT
  ACTTCAGCCGTGGCATCATGATGGCCATCCTTGTCAACACGCTGAGCATGGGCGTGGAGTACCATGAGCA
  GCCCGAGGAGCTGACTAATGCTCTGGAGATCAGCAACATCGTGTTCACCAGCATGTTTGCCCTGGAGATG
  CTGCTGAAGCTGCTGGCCTGCGGCCCTCTGGGCTACATCCGGAACCCGTACAACATCTTCGACGGCATCA
  TCGTGGTCATCAGCGTCTGGGAGATCGTGGGGCAGGCGGACGGTGGCTTGTCTGTGCTGCGCACCTTCCG
  GCTGCTGCGTGTGCTGAAGCTGGTGCGCTTTCTGCCAGCCCTGCGGCGCCAGCTCGTGGTGCTGGTGAAG
  ACCATGGACAACGTGGCTACCTTCTGCACGCTGCTCATGCTCTTCATTTTCATCTTCAGCATCCTGGGCA
  TGCACCTTTTCGGCTGCAAGTTCAGCCTGAAGACAGACACCGGAGACACCGTGCCTGACAGGAAGAACTT
  CGACTCCCTGCTGTGGGCCATCGTCACCGTGTTCCAGATCCTGACCCAGGAGGACTGGAACGTGGTCCTG
  TACAACGGCATGGCCTCCACCTCCTCCTGGGCCGCCCTCTACTTCGTGGCCCTCATGACCTTCGGCAACT
  ATGTGCTCTTCAACCTGCTGGTGGCCATCCTCGTGGAGGGCTTCCAGGCGGAGGGCGATGCCAACAGATC
  CGACACGGACGAGGACAAGACGTCGGTCCACTTCGAGGAGGACTTCCACAAGCTCAGAGAACTCCAGACC
  ACAGAGCTGAAGATGTGTTCCCTGGCCGTGACCCCCAACGGGCACCTGGAGGGACGAGGCAGCCTGTCCC
  CTCCCCTCATCATGTGCACAGCTGCCACGCCCATGCCTACCCCCAAGAGCTCACCATTCCTGGATGCAGC
  CCCCAGCCTCCCAGACTCTCGGCGTGGCAGCAGCAGCTCCGGGGACCCGCCACTGGGAGACCAGAAGCCT
  CCGGCCAGCCTCCGAAGTTCTCCCTGTGCCCCCTGGGGCCCCAGTGGCGCCTGGAGCAGCCGGCGCTCCA
  GCTGGAGCAGCCTGGGCCGTGCCCCCAGCCTCAAGCGCCGCGGCCAGTGTGGGGAACGTGAGTCCCTGCT
  GTCTGGCGAGGGCAAGGGCAGCACCGACGACGAAGCTGAGGACGGCAGGGCCGCGCCCGGGCCCCGTGCC
  ACCCCACTGCGGCGGGCCGAGTCCCTGGACCCACGGCCCCTGCGGCCGGCCGCCCTCCCGCCTACCAAGT
  GCCGCGATCGCGACGGGCAGGTGGTGGCCCTGCCCAGCGACTTCTTCCTGCGCATCGACAGCCACCGTGA
  GGATGCAGCCGAGCTTGACGACGACTCGGAGGACAGCTGCTGCCTCCGCCTGCATAAAGTGCTGGAGCCC
  TACAAGCCCCAGTGGTGCCGGAGCCGCGAGGCCTGGGCCCTCTACCTCTTCTCCCCACAGAACCGGTTCC
  GCGTCTCCTGCCAGAAGGTCATCACACACAAGATGTTTGATCACGTGGTCCTCGTCTTCATCTTCCTCAA
  CTGCGTCACCATCGCCCTGGAGAGGCCTGACATTGATCCCGGCAGCACCGAGCGGGTCTTCCTCAGCGTC
  TCCAATTACATCTTCACGGCCATCTTCGTGGCGGAGATGATGGTGAAGGTGGTGGCCCTGGGGCTGCTGT
  CCGGCGAGCACGCCTACCTGCAGAGCAGCTGGAACCTGCTGGATGGGCTGCTGGTGCTGGTGTCCCTGGT
  GGACATTGTCGTGGCCATGGCCTCGGCTGGTGGCGCCAAGATCCTGGGTGTTCTGCGCGTGCTGCGTCTG
  CTGCGGACCCTGCGGCCTCTGAGGGTCATCAGCCGGGCCCCGGGCCTCAAGCTGGTGGTGGAGACGCTGA
  TATCATCACTCAGGCCCATTGGGAACATCGTCCTCATCTGCTGCGCCTTCTTCATCATTTTTGGCATTTT
  GGGTGTGCAGCTCTTCAAAGGGAAGTTCTACTACTGCGAGGGCCCCGACACCAGGAACATCTCCACCAAG
  GCACAGTGCCGGGCCGCCCACTACCGCTGGGTGCGACGCAAGTACAACTTCGACAACCTGGGCCAGGCCC
  TGATGTCGCTGTTCGTGCTGTCATCCAAGGATGGATGGGTGAACATCATGTACGACGGGCTGGATGCCGT
  GGGTGTCGACCAGCAGCCTGTGCAGAACCACAACCCCTGGATGCTGCTGTACTTCATCTCCTTCCTGCTC
  ATCGTCAGCTTCTTCGTGCTCAACATGTTCGTGGGCGTCGTGGTCGAGAACTTCCACAAGTGCCGGCAGC
  ACCAGGAGGCGGAGGAGGCGCGGCGGCGAGAGGAGAAGCGGCTGCGGCGCCTAGAGAGGAGGCGCAGGAA
  GGCCCAGCGCCGGCCCTACTATGCCGACTACTCGCCCACGCGCCGCTCCATTCACTCGCTGTGCACCAGC
  CACTATCTCGACCTCTTCATCACCTTCATCATCTGTGTCAACGTCATCACCATGTCCATGGAGCACTATA
  ACCAACCCAAGTCGCTGGACGAGGCCCTCAAGTACTGCAACTACGTCTTCACCATCGTGTTTGTCTTCGA
  GGCTGCACTGAAGCTGGTAGCATTTGGGTTCCGTCGGTTCTTCAAGGACAGGTGGAACCAGCTGGACCTG
  GCCATCGTGCTGCTGTCACTCATGGGCATCACGCTGGAGGAGATAGAGATGAGCGCCGCGCTGCCCATCA
  ACCCCACCATCATCCGCATCATGCGCGTGCTTCGCATTGCCCGTGTGCTGAAGCTGCTGAAGATGGCTAC
  GGGCATGCGCGCCCTGCTGGACACTGTGGTGCAAGCTCTCCCCCAGGTGGGGAACCTGGGCCTTCTTTTC
  ATGCTCCTGTTTTTTATCTATGCTGCGCTGGGAGTGGAGCTGTTCGGGAGGCTGGAGTGCAGTGAAGACA
  ACCCCTGCGAGGGCCTGAGCAGGCACGCCACCTTCAGCAACTTCGGCATGGCCTTCCTCACGCTGTTCCG
  CGTGTCCACGGGGGACAACTGGAACGGGATCATGAAGGACACGCTGCGCGAGTGCTCCCGTGAGGACAAG
  CACTGCCTGAGCTACCTGCCGGCCCTGTCGCCCGTCTACTTCGTGACCTTCGTGCTGGTGGCCCAGTTCG
  TGCTGGTGAACGTGGTGGTGGCCGTGCTCATGAAGCACCTGGAGGAGAGCAACAAGGAGGCACGGGAGGA
  TGCGGAGCTGGACGCCGAGATCGAGCTGGAGATGGCGCAGGGCCCCGGGAGTGCACGCCGGGTGGACGCG
  GACAGGCCTCCCTTGCCCCAGGAGAGTCCGGGCGCCAGGGACGCCCCAAACCTGGTTGCACGCAAGGTGT
  CCGTGTCCAGGATGCTCTCGCTGCCCAACGACAGCTACATGTTCAGGCCCGTGGTGCCTGCCTCGGCGCC
  CCACCCCCGCCCGCTGCAGGAGGTGGAGATGGAGACCTATGGGGCCGGCACCCCCTTGGGCTCCGTTGCC
  TCTGTGCACTCTCCGCCCGCAGAGTCCTGTGCCTCCCTCCAGATCCCATTGGCTGTGTCGTCCCCAGCCA
  GGAGCGGCGAGCCCCTCCACGCCCTGTCCCCTCGGGGCACAGCCCGCTCCCCCAGTCTCAGCCGGCTGCT
  CTGCAGACAGGAGGCTGTGCACACCGATTCCTTGGAAGGGAAGATTGACAGCCCTAGGGACACCCTGGAT
  CCTGCAGAGCCTGGTGAGAAAACCCCGGTGAGGCCGGTGACCCAGGGGGGCTCCCTGCAGTCCCCACCAC
  GCTCCCCACGGCCCGCCAGCGTCCGCACTCGTAAGCATACCTTCGGACAGCGCTGCGTCTCCAGCCGGCC
  GGCGGCCCCAGGCGGAGAGGAGGCCGAGGCCTCGGACCCAGCCGACGAGGAGGTCAGCCACATCACCAGC
  TCCGCCTGCCCCTGGCAGCCCACAGCCGAGCCCCATGGCCCCGAAGCCTCTCCGGTGGCCGGCGGCGAGC
  GGGACCTGCGCAGGCTCTACAGCGTGGATGCTCAGGGCTTCCTGGACAAGCCGGGCCGGGCAGACGAGCA
  GTGGCGGCCCTCGGCGGAGCTGGGCAGCGGGGAGCCTGGGGAGGCGAAGGCCTGGGGCCCTGAGGCCGAG
  CCCGCTCTGGGTGCGCGCAGAAAGAAGAAGATGAGCCCCCCCTGCATCTCGGTGGAACCCCCTGCGGAGG
  ACGAGGGCTCTGCGCGGCCCTCCGCGGCAGAGGGCGGCAGCACCACACTGAGGCGCAGGACCCCGTCCTG
  TGAGGCCACGCCTCACAGGGACTCCCTGGAGCCCACAGAGGGCTCAGGCGCCGGGGGGGACCCTGCAGCC
  AAGGGGGAGCGCTGGGGCCAGGCCTCCTGCCGGGCTGAGCACCTGACCGTCCCCAGCTTTGCCTTTGAGC
  CGCTGGACCTCGGGGTCCCCAGTGGAGACCCTTTCTTGGACGGTAGCCACAGTGTGACCCCAGAATCCAG
  AGCTTCCTCTTCAGGGGCCATAGTGCCCCTGGAACCCCCAGAATCAGAGCCTCCCATGCCCGTCGGTGAC
  CCCCCAGAGAAGAGGCGGGGGCTGTACCTCACAGTCCCCCAGTGTCCTCTGGAGAAACCAGGGTCCCCCT
  CAGCCACCCCTGCCCCAGGGGGTGGTGCAGATGACCCCGTG
  
  ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA
  Protein Sequence

  >RG218260 representing NM_001005407
  Red=Cloning site Green=Tags(s)
  
  MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAPGREAERGSELGVSPSESPAAERGAELGADEEQRV
  PYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFD
  AFIFAFFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAI
  NRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQ
  TEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSG
  DSNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIAT
  QFSETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKV
  DPSAVQGQGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPP
  SPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSP
  GPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKSC
  PYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPG
  EPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEM
  LLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK
  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL
  YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQT
  TELKMCSLAVTPNGHLEGRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKP
  PASLRSSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRA
  TPLRRAESLDPRPLRPAALPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEP
  YKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSV
  SNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRL
  LRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTK
  AQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLL
  IVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTS
  HYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDL
  AIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLF
  MLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDK
  HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAEIELEMAQGPGSARRVDA
  DRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLGSVA
  SVHSPPAESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLD
  PAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSHITS
  SACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAE
  PALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAA
  KGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPMPVGD
  PPEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADDPV
  
  TRTRPLE - GFP Tag - V
• Restriction Sites: RsrII-MluI Cloning Scheme for this gene Plasmid Map
• ACCN: NM_001005407
• ORF Size: 7041 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001005407.1, NP_001005407.1
• RefSeq Size: 8079 bp
• RefSeq ORF: 7044 bp
• Locus ID: 8912
• UniProt ID: O95180
• Cytogenetics: 16p13.3
• Protein Families: Druggable Genome, Ion Channels: Calcium, Transmembrane
• Protein Pathways: Calcium signaling pathway, MAPK signaling pathway
• Gene Summary: This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]