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Usp9x (NM_009481) Mouse Tagged ORF Clone
CAT#: MG226439
- TrueORF®
Usp9x (tGFP-tagged) - Mouse ubiquitin specific peptidase 9 X chromosome (Usp9x), (10ug). Note: ORF is codon optimized
ORF Plasmid: DDK
"NM_009481" in other vectors (2)
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Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | TurboGFP |
| Symbol | Usp9x |
| Synonyms | 5730589N07Rik; AA407302; AA407699; AL022658; AL022749; Dffrx; FAF-X; Fafl |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MG226439 representing NM_009481, codon optimized.
Due to the complexity of NM_009481, the ORF clone is codon optimized for mammalian Expression. The nucleotide sequence differs from the reference sequence, yet the amino acid sequence remains identical. Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGACAGCCACGACTCGTGGCTCTCCAGTTGGAGGGAATGACAACCAGGGCCAAGCCCCTGATGGACAGT CTCAGCCCCCCCTCCAACAGAATCAGACTTCATCGCCTGATTCGTCCAATGAAAATTCCCCTGCAACTCC TCCTGATGAGCAAGGTCAAGGTGATGCTCCTCCACAGATTGAAGATGAGGAACCTGCATTTCCACACACT GACTTGGCAAAGTTAGATGATATGATCAACAGGCCTCGATGGGTTGTTCCAGTTTTGCCGAAAGGGGAAT TAGAAGTGCTTTTAGAAGCTGCTATTGATCTTAGTAAGAAAGGCCTTGATGTTAAAAGTGAAGCATGTCA GCGATTTTTCCGAGATGGGCTAACGATCTCATTTACAAAAATCCTGACAGATGAAGCAGTGAGTGGCTGG AAGTTTGAAATTCACAGATGCATTATTAACAATACTCATCGCCTGGTGGAGCTATGTGTGGCTAAGTTAG CCCAAGACTGGTTTCCACTTCTAGAACTTCTTGCCATGGCCTTAAATCCTCATTGCAAATTCCATATCTA CAATGGTACACGTCCCTGCGAGTCAGTGTCCTCAAGTGTTCAGTTGCCTGAAGATGAACTCTTTGCTCGT TCTCCAGACCCTCGATCACCAAAAGGTTGGCTAGTGGATCTCCTCAACAAGTTTGGCACTTTAAATGGAT TCCAGATACTGCACGATCGTTTTATTAATGGATCAGCATTAAACGTTCAGATAATTGCAGCCCTTATTAA ACCATTTGGACAGTGCTATGAGTTTCTTACTCTTCACACAGTGAAAAAGTACTTTCTTCCAATAATAGAA ATGGTTCCACAGTTTTTAGAAAACTTAACTGATGAAGAGCTGAAGAAAGAAGCAAAGAATGAAGCCAAAA ATGATGCTCTTTCAATGATTATTAAATCATTGAAGAATTTAGCTTCGCGGGTTCCTGGACAAGAAGAAAC TGTAAAAAACTTAGAAATATTTAGGTTAAAAATGATACTTAGATTGTTGCAAATTTCTTCTTTCAATGGA AAGATGAATGCACTGAATGAGGTTAATAAGGTGATTTCCAGTGTGTCATACTATACCCATCGGCATGGCA GTTCTGAGGATGAAGAGTGGCTTACAGCAGAGAGGATGGCTGAATGGATACAGCAGAACAATATTTTATC CATAGTTTTACGAGATAGCCTTCATCAACCACAGTATGTAGAGAAACTAGAAAAGATTCTTCGCTTTGTC ATAAAAGAAAAAGCTCTGACCTTGCAAGATCTTGATAATATCTGGGCAGCACAGGCAGGGAAACATGAAG CCATTGTAAAGAATGTACATGATCTACTGGCCAAATTGGCATGGGATTTTTCTCCTGAACAACTTGATCA TCTTTTTGATTGCTTTAAGGCCAGTTGGACAAATGCAAGTAAAAAGCAACGTGAAAAGCTCCTTGAGCTG ATTCGTCGTCTTGCAGAAGATGATAAAGATGGTGTGATGGCACATAAAGTATTGAACCTTCTGTGGAATC TAGCTCACAGTGATGATGTGCCTGTAGATATCATGGATTTGGCTCTCAGTGCTCACATCAAAATACTAGA TTATAGTTGCTCCCAGGACCGGGACACCCAAAAGATCCAGTGGATTGATCGCTTCATAGAAGAACTTCGC ACAAATGACAAATGGGTCATTCCTGCACTGAAACAAATTAGAGAAATTTGTAGTTTGTTTGGTGAAGCAC CTCAAAATTTGAGTCAAAGTCAGCGAAGTCCCCATGTATTTTATCGCCATGACTTAATCAATCAACTTCA GCACAATCATGCCCTAGTTACTTTGGTAGCAGAAAACCTTGCAACTTACATGGAAAGCATGAGAATGTAT GGCAGAGACAATGAAGACTATGACCCACAAACTGTGAGACTGGGAAGTAGATATAGTCATGTTCAAGAAG TCCAAGAACGGCTTAACTTTCTTAGGTTTTTATTGAAGGATGGCCAGCTGTGGCTGTGTGCTCCACAGGC AAAACAAATATGGAAGTGCTTAGCAGAGAATGCGGTTTATCTTTGTGATCGTGAAGCCTGTTTTAAGTGG TATTCCAAATTAATGGGAGACGAACCTGACTTAGATCCTGATATCAATAAGGACTTCTTTGAAAGTAATG TGCTTCAGCTTGATCCTTCCCTGTTAACTGAAAATGGGATGAAGTGTTTTGAGAGATTCTTCAAAGCTGT GAATTGTCGAGAAGGAAAACTAGTAGCAAAAAGAAGAGCCTACATGATGGATGATTTGGAATTGATAGGA TTAGACTATCTTTGGAGAGTTGTAATTCAGAGTAATGATGATATTGCCTGCCGAGCTATTGATCTCCTTA AAGAGATATACACAAACCTTGGTCCAAGGCTGCAGGTCAATCAGGTGGTGATCCATGAAGACTTCATTCA GTCTTGCTTTGATCGTTTGAAAGCCTCTTATGACACATTGTGTGTTTTGGATGGTGACAAAGACAGTATT AATTGTGCAAGACAGGAAGCTGTTCGAATGGTCCGAGTGTTAACTGTTCTAAGAGAATATATAAATGAAT GTGACAGTGATTATCATGAAGAAAGAACAATTTTGCCTATGTCCAGGGCTTTCCGAGGCAAGCATCTCTC CTTTATTGTTCGGTTTCCGAACCAGGGAAGACAAGTCGATGACTTGGAGGTCTGGTCACACACAAACGAT ACGATCGGGAGCGTTCGGCGGTGCATTCTCAATCGGATTAAGGCCAACGTGGCCCACACAAAGATTGAGC TGTTCGTTGGGGGAGAGCTGATAGATCCTGGCGACGATCGGAAGCTGATCGGGCAGCTTAACCTGAAGGA CAAAAGTCTGATTACTGCGAAGCTCACACAGATTTCTTCCAACATGCCTAGCAGCCCTGACAGCTCATCT GACAGCTCAACAGGATCACCTGGGAATCATGGCAACCACTATTCCGACGGACCCAATCCAGAGGTTGAGA GCTGCTTGCCTGGCGTGATCATGTCACTGCACCCGAGGTACATCAGCTTCCTTTGGCAGGTGGCAGACCT GGGGAGCTCACTGAACATGCCTCCTCTCAGAGACGGGGCGAGGGTGTTGATGAAACTGATGCCCCCCGAC TCTACCACTATCGAAAAGCTGAGAGCCATCTGCTTGGACCACGCCAAATTGGGCGAATCTTCATTGTCTC CAAGCCTGGATTCCCTCTTTTTTGGCCCGTCAGCCTCTCAGGTCCTGTACCTCACAGAGGTAGTGTACGC CCTTCTCATGCCTGCAGGCGCCCCATTGACCGATGACAGCTCTGACTTTCAGTTCCACTTCCTGAAATCT GGCGGCCTGCCACTTGTCCTTAGCATGCTGACCCGAAATAACTTCCTCCCAAATGCCGATATGGAGACTA GAAGAGGCGCCTACCTGAACGCATTGAAGATTGCGAAATTGCTCCTCACAGCAATCGGCTACGGCCACGT GCGGGCAGTTGCAGAGGCTTGTCAGCCCGGAGTGGAAGGCGTAAATCCTATGACATCTGTGAACCAGGTA ACGCATGATCAGGCAGTCGTGTTGCAGAGCGCCCTCCAGTCCATACCTAATCCAAGTAGCGAGTGCATGC TGCGCAACGTATCCGTTCGACTCGCTCAGCAGATTAGTGACGAAGCTAGTCGCTATATGCCCGACATCTG CGTGATTAGAGCCATCCAGAAGATTATCTGGACTAGCGGATGCGGAGGGCTCCAGCTGGTGTTCAGTCCT AATGAGGAGGTGACCAAGATTTACGAAAAGACTAACGCCGGCAATGAACCTGATCTCGAGGACGAACAGG TCTGCTGCGAAGCTCTCGAGGTGATGACTCTGTGCTTTGCCTTGATCCCTACCGCACTGGACGCTCTGTC CAAGGAGAAAGCTTGGCAGACCTTCATTATTGATCTGCTGCTGCATTGTCACAGCAAGACCGTGAGACAG GTTGCCCAAGAACAGTTTTTTCTGATGTGTACTAGATGTTGCATGGGGCACAGGCCTCTCTTGTTCTTCA TAACATTGCTTTTTACCGTGCTGGGTTCTACAGCTAGGGAACGCGCCAAGCATAGCGGGGATTACTTCAC CCTCCTCAGGCACCTGCTGAACTACGCCTATAACAGCAACATTAATGTTCCAAACGCTGAAGTCCTGTTG AACAACGAGATAGACTGGCTCAAAAGGATTCGCGACGACGTCAAACGCACCGGTGAAACTGGAGTCGAGG AAACTATCCTTGAAGGACATCTGGGTGTCACTAAGGAACTCTTGGCCTTCCAAACTCCCGAGAAGAAGTT TCATATCGGCTGTGAAAAAGGTGGTGCTAACTTGATCAAGGAACTGATCGACGATTTTATTTTTCCTGCT TCCAATGTTTACCTCCAGTACATGAGGAACGGAGAACTTCCTGCCGAACAGGCAATTCCAGTGTGCGGTT CTCCGGCAACCATCAATGCGGGCTTTGAGCTGCTCGTTGCACTCGCTGTCGGCTGTGTGCGGAATCTTAA ACAGATCGTCGATAGCCTGACAGAAATGTATTACATTGGCACTGCTATAACCACTTGTGAGGCACTGACA GAGTGGGAGTACCTGCCACCTGTCGGCCCTCGGCCCCCTAAGGGCTTTGTCGGCCTGAAGAACGCTGGGG CTACGTGCTACATGAATTCAGTGATTCAGCAGCTGTATATGATTCCAAGCATTAGAAATGGTATCCTGGC TATTGAAGGCACCGGTTCAGATGTAGATGATGACATGAGCGGCGACGAAAAGCAAGACAATGAATCCAAT GTAGATCCCCGGGACGACGTCTTCGGCTACCCCCAGCAGTTCGAAGACAAACCTCCTCTTTCTAAAACAG AAGACCGGAAGGAGTATAACATCGGGGTGCTTAGACACCTTCAGGTGATTTTTGGCCACCTTGCGGCTAG CCGATTGCAATATTATGTTCCTCGGGGATTCTGGAAACAGTTTCGCCTGTGGGGAGAACCGGTCAACCTG CGCGAGCAGCACGACGCCCTTGAATTCTTCAACAGTCTCGTAGACAGTTTGGACGAGGCCCTGAAAGCCC TTGGACATCCGGCAATGCTTAGCAAGGTGTTGGGGGGGTCATTTGCTGACCAGAAGATTTGTCAAGGCTG CCCTCACCGATACGAGTGTGAGGAGTCTTTCACCACTCTCAATGTGGATATCAGGAATCACCAAAACTTG TTGGACTCCCTTGAACAGTACGTCAAGGGAGATCTGTTGGAAGGTGCTAATGCATATCACTGTGAGAAGT GCAACAAGAAGGTAGACACCGTTAAGCGGCTGCTGATTAAGAAGCTTCCTCCTGTGCTGGCAATCCAGTT GAAGCGATTCGACTATGATTGGGAAAGGGAGTGCGCCATTAAATTTAACGACTACTTCGAATTCCCCCGC GAATTGGATATGGAACCTTATACCGTAGCTGGAGTGGCCAAGCTGGAGGGAGACAACGTGAACCCTGAAT CCCAACTGATACAGCAGAATGAACAGTCAGAGTCCGAGAAAGCCGGGTCTACTAAGTATCGCCTGGTTGG GGTACTGGTGCACTCTGGACAGGCGAGCGGCGGGCACTATTATTCATATATCATCCAGCGAAATGGAGGG GACGGCGAAAAGAATAGGTGGTACAAGTTTGACGATGGCGACGTGACGGAATGTAAAATGGATGATGATG AAGAGATGAAGAACCAGTGTTTCGGGGGAGAGTACATGGGTGAGGTGTTCGATCATATGATGAAGAGAAT GAGCTATCGGCGCCAGAAGCGGTGGTGGAATGCGTACATTCTCTTTTACGAACGCATGGACACTATAGGA CACGACGATGAAGTCATACGGTACATCTCAGAAATCGCAATCACGACCCGACCGCATCAGATCGTGATGC CCAGCGCTATCGAGAGGTCAGTCCGGAAGCAAAACGTCCAGTTTATGCATAACAGGATGCAGTATTCACT GGAGTATTTTCAGTTTATGAAGAAGCTGCTTACATGCAATGGGGTCTACCTTAACCCTCCACCTGGACAG GACCATCTGTCTCCCGAAGCTGAAGAGATTACTATGATCAGCATCCAGCTCGCTGCTCGGTTCTTGTTCA CGACCGGGTTTCATACCAAGAAAATTGTGCGGGGCAGTGCGTCAGATTGGTACGACGCTCTCTGCATCCT CCTGCGACACTCTAAGAACGTGCGATTTTGGTTCGCACATAACGTCCTCTTCAACGTGTCCAACCGGTTC TCCGAATATCTGTTGGAATGCCCTAGCGCCGAGGTGCGGGGGGCTTTTGCTAAGTTGATCGTTTTCATCG CTCACTTTTCCCTCCAGGATGGCCCTTGCCCCTCACCTTTTGCTTCTCCCGGGCCTAGCAGCCAGGCCTA TGATAACCTCTCCCTGAGTGACCACCTGTTGCGAGCCGTGCTTAACCTCCTGCGACGAGAAGTAAGTGAA CACGGGCGACATCTGCAACAATACTTCAACCTCTTCGTCATGTACGCAAATCTGGGCGTCGCGGAAAAGA CTCAGCTCCTGAAACTGAGCGTGCCAGCTACATTCATGTTGGTTAGCTTGGACGAGGGCCCGGGTCCACC GATCAAGTACCAGTACGCTGAACTGGGTAAGCTCTATTCCGTTGTTAGTCAGCTCATCCGCTGCTGCAAT GTATCAAGCCGCATGCAGAGCTCTATCAACGGAAATCCATCACTCCCTAACCCCTTCGGCGACCCCAACC TTAGTCAGCCAATTATGCCAATCCAACAGAACGTAGTGGACATCCTGTTTGTAAGAACTTCATATGTAAA AAAGATAATCGAAGACTGTTCTAATTCTGATGAGACTGTCAAGCTGCTCCGATTCTGTTGTTGGGAGAAC CCGCAATTTAGCTCCACAGTGTTGTCCGAACTGCTCTGGCAGGTGGCCTACTCATATACCTACGAACTTC GCCCATATCTCGACCTGCTGTTGCAGATCCTGCTGATTGAGGACTCATGGCAAACGCACCGCATTCATAA CGCTTTGAAAGGGATTCCAGACGATCGAGATGGCCTTTTCGACACCATCCAGCGGTCAAAAAACCACTAC CAGAAGCGGGCATACCAGTGTATCAAGTGTATGGTCGCTCTTTTTTCAAGTTGTCCTGTGGCGTACCAGA TCCTGCAGGGGAACGGGGATCTGAAGCGGAAGTGGACTTGGGCCGTGGAATGGCTGGGAGACGAGCTGGA AAGACGCCCCTATACGGGCAACCCTCAATATACCTATAATAACTGGTCACCACCAGTCCAGTCAAATGAG ACGAGCAACGGGTACTTCCTGGAACGCTCTCACTCTGCAAGGATGACACTCGCAAAAGCGTGCGAGCTGT GTCCTGAGGAAGAACCCGACGACCAGGACGCACCAGACGAGCATGAAAGCCCACCTCCGGAAGATGCGCC TCTGTATCCACATAGCCCTGGGTCCCAGTACCAACAAAACAATCACGTGCATGGACAGCCGTATACTGGC CCTGCAGCCCATCATATGAATAACCCTCAGAGGACCGGCCAGCGAGCCCAAGAAAACTACGAGGGCGGCG AGGAGGTCAGTCCTCCTCAAACCAAGGACCAA ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG226439 representing NM_009481
Red=Cloning site Green=Tags(s) MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQIEDEEPAFPHT DLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGW KFEIHRCIINNTHRLVELCVAKLAQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFAR SPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIE MVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNG KMNALNEVNKVISSVSYYTHRHGSSEDEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFV IKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLEL IRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELR TNDKWVIPALKQIREICSLFGEAPQNLSQSQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRMY GRDNEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKW YSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIG LDYLWRVVIQSNDDIACRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSI NCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFIVRFPNQGRQVDDLEVWSHTND TIGSVRRCILNRIKANVAHTKIELFVGGELIDPGDDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSS DSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPD STTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLTDDSSDFQFHFLKS GGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTSVNQV THDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWTSGCGGLQLVFSP NEEVTKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQ VAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLL NNEIDWLKRIRDDVKRTGETGVEETILEGHLGVTKELLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPA SNVYLQYMRNGELPAEQAIPVCGSPATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALT EWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESN VDPRDDVFGYPQQFEDKPPLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNL REQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNL LDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPR ELDMEPYTVAGVAKLEGDNVNPESQLIQQNEQSESEKAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGG DGEKNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIG HDDEVIRYISEIAITTRPHQIVMPSAIERSVRKQNVQFMHNRMQYSLEYFQFMKKLLTCNGVYLNPPPGQ DHLSPEAEEITMISIQLAARFLFTTGFHTKKIVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRF SEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSE HGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCN VSSRMQSSINGNPSLPNPFGDPNLSQPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFCCWEN PQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHY QKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNE TSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTG PAAHHMNNPQRTGQRAQENYEGGEEVSPPQTKDQ TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_009481 |
| ORF Size | 7662 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_009481.2, NP_033507.2 |
| RefSeq Size | 11903 bp |
| RefSeq ORF | 7665 bp |
| Locus ID | 22284 |
| UniProt ID | P70398 |
| Cytogenetics | X 7.95 cM |
| Gene Summary | Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (By similarity). Involved in axonal growth and neuronal cell migration (By similarity) (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158).[UniProtKB/Swiss-Prot Function] |
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