Ifnar1 (NM_010508) Mouse Untagged Clone

CAT#: MC204749

Ifnar1 (untagged) - Mouse interferon (alpha and beta) receptor 1 (Ifnar1), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Ifnar1
• Synonyms: CD118; Ifar; Ifnar; Ifrc; Infar
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC052217
  GGCCTAGCTGCCCAGAGGTAGTCTCCAGCTCCGCGGTGCTGCTGAGGAGAAGGAGGAGAATGTGAGCCGC CGCCCGGCCTCCCAAGACGATGCTCGCTGTCGTGGGCGCGGCGGCCCTGGTGCTGGTGGCCGGGGCGCCT TGGGTGCTACCCTCAGCTGCAGGTGGAGAAAATCTGAAACCTCCTGAGAATATAGACGTCTACATTATAG ATGACAACTACACCCTAAAGTGGAGCAGCCACGGAGAGTCAATGGGCAGTGTGACCTTTTCAGCAGAATA TCGAACAAAAGACGAGGCGAAGTGGTTAAAAGTGCCTGAATGTCAACATACTACAACGACCAAGTGTGAA TTCTCTTTACTGGACACAAATGTGTATATCAAAACACAGTTTCGTGTCAGAGCAGAGGAAGGGAACAGCA CATCTTCGTGGAATGAGGTTGATCCGTTTATTCCATTCTACACAGCTCACATGAGCCCCCCAGAAGTACG TTTAGAAGCTGAAGATAAAGCCATACTAGTCCACATCTCTCCTCCCGGACAAGACGGGAACATGTGGGCA CTGGAGAAACCTTCCTTCAGTTACACCATACGAATCTGGCAGAAGTCTTCCAGTGACAAAAAAACTATTA ACTCTACGTATTATGTAGAAAAGATACCAGAACTCTTGCCAGAGACTACTTACTGTTTAGAAGTTAAAGC AATACATCCGTCACTTAAGAAACACAGCAATTACAGCACTGTGCAGTGTATAAGCACCACAGTGGCAAAT AAAATGCCTGTGCCAGGAAATCTCCAAGTGGATGCCCAAGGCAAGAGCTATGTCCTGAAATGGGACTACA TTGCGTCTGCAGACGTGCTCTTCAGGGCACAGTGGCTTCCTGGCTATTCAAAAAGCAGTTCTGGAAGCCG TTCAGATAAATGGAAACCAATACCAACCTGTGCAAATGTCCAGACTACGCACTGTGTCTTTTCTCAAGAT ACTGTCTACACAGGAACGTTCTTTCTCCATGTACAAGCCTCAGAGGGAAATCACACATCCTTTTGGTCTG AAGAGAAGTTTATTGATTCTCAAAAACACATTCTCCCTTCTCCTCCGGTCATTACTGTCACCGCCATGAG TGACACCTTGCTTGTTTATGTCAACTGTCAGGACAGCACATGTGATGGACTCAATTACGAAATCATCTTT TGGGAAAACACTTCCAATACTAAGATAAGCATGGAGAAGGATGGCCCAGAGTTCACCCTCAAGAACCTGC AGCCGCTGACTGTGTACTGTGTCCAGGCCAGAGTGCTCTTCAGGGCCCTGCTGAATAAGACCAGCAACTT CAGTGAAAAGCTGTGTGAGAAAACACGTCCAGGAAGTTTTTCCACGATCTGGATTATAACTGGATTAGGT GTTGTGTTCTTCTCTGTCATGGTCCTTTATGCTTTGAGGAGCGTCTGGAAATACCTGTGTCATGTGTGCT TCCCACCACTCAAGCCTCCCCGCAGTATTGATGAGTTTTTCTCTGAGCCGCCTTCAAAAAACCTTGTACT TCTGACGGCTGAGGAGCACACGGAAAGATGCTTCATCATTGAGAATACAGACACGGTCGCTGTAGAAGTA AAGCACGCGCCTGAGGAGGACCTCAGGAAGTACAGCTCACAGACCAGCCAGGACTCGGGCAACTATTCCA ACGAAGGGGAGGAGAGTGTGGGCACCGAGAGCGGCCAAGCTGTGCTCTCCAAAGCTCCCTGCGGGGGGCC ATGCAGCGTGCCTAGCCCTCCTGGGACCTTGGAAGACGGGACCTGCTTCCTGGGAAATGAAAAATATCTT CAGAGCCCAGCCCTGAGGACAGAGCCAGCTCTTCTCTGCTGACAGGTGCTCGGCCCAGGCTGGGGGCCGT GTGGAGGAGACAGACTTATCTGAAGTGGCTGCCAGCTTCTGCTGCCAGCTGGAAGCCCTGGGTGCTGTTT GTGCCACAGATGAGGCTCACTGATGTCAGGCATCTGGTGGTTCTGTCTCGGTGTTTGTCCTCTAGGTGAC ATTTAGAACATTCCGATTTTTAATCCTGCCGTAGCCCCTCAGTGTGTCACAGGTACCATTGTCTACAGCC GCGCTTCCTAACCCATACCTCACCACAGCCGTGGCTTCTGACCAGAAGTCACTGAAACCATGGAGAAAGG GGACACTAACTGGAGGAGCTGGCGTTGTTTAAGATCTCTGTGGCCTGGGTGTGCCCGTTGTACTCTAGTA CTTGCAGAACTAGAAAATGCCAGGGACAAAAAGCAGGCATGAACCATTCAGTAAGAGAGAAGCTAGTGAA CCTGATGGTGAAAGAAGACCGTGTCCAGTCAGTGTTTGTGTGAAGGCCCTGTGCTGCTCTCTGTAGCCTT CCCGTGGTACTTATAAAACCAGGCCGAACCCTGTCCTCTGTCCGGCACTATTCAGGTCCCTTCCCAGCTC CAGGTACTTAAAAAACAAAGTGTTGGGTCCTGGGGTGAGGGAACAGCTTCGACGGCACAGTGCTGCCTGC AGGCGCCTATAAGTGACCTTAGATGAATGCTCCATGAGCATCTTCGGTAGGCAGGACATCCAGCAGTGCT GGTGGCTCCAGGGCAGACTCAGTTGCAGGCCAAAAAGGAAGAGAGAGGAGTCATAGCCCTGCCCCAATCG AGCTTGTTGCTCGCTGCACTGCGCCTTTGTAATCAATCTTGGTTTTTTTGTTTTGTTTTGTTTTTTTTAA CTTTTAGGTGATAACATATTCTCAGATATAGCACACAAGAGACACTACACAAATTACGTCTGAAAGTTTT GATAGAAAAGAGCTTTTGACTGGGGTAGACAGCTTGCTCCTCACTACTACCTTGTATCTCAGTCTCCTCA ACAGAGAGAGAATGCAGATTGATTTTCATCCTGAGTTTTATTTTCTTGCCCGGTTTCTGGGTTCGGGTGT GCTTTCAAGGCTCTGAACAGCTTGTCTGCCCACAGGGGAGCCCGGAGACCCAGCCTTTTGGCTAAATGTT GCAGGTTCCTGTACTTGAAGGACTCCAGCTCCTCTGTAGAGGGCATGGTCATCGCGGTCTGCAATCACGC TGATACCCAGAAAAATGGCCACACAACTCAAATCTGGTGCCATGCTTTAATAATTCTACCCAGCACGGCC CAGCCCTGTTCACGGCGGAAAAGCTCCTTCTGCCAGGACAGCCTGTGAAGAAACAAGACCTCCGAGGACG TGGCCAAGGAAGGCCCAGATGCTAGCGGGAAGTTGTTAGTTGGCACTCTTTCATCTCTCAACAACTGTGA CACAGGTCTTCAGGGTGAAGCCCAAAGCAGCTATCGGTTGCAGCAGCGGGTAAGGAGGGGGCTTCACCTG AGCCTGGCCTTCTGGGCGAGCAGTTCTACCTGCACACTTCAAGACAGCCTCCATGACCCTTTTCACGGCA CACCGCCTGCTTTTGGTGTGACCGGGGTTTCCTGTGCAGGCACATGTTCTTAAGGAATGCCATGCACACA GGCCTGAAGAGCTGGCTCAGCGGGTAGAGCACAGGTTGCTCTTGTCTGGGATCTGAGCTCTGTCCCCAGC ACCCACAGAGTGCTTCTGGTTGCCTCAGACTCCAGGGGTGCACAAGGCCATGTAAGCAAAGACATGTAAG CAAAGACAGTTGTACACAGAGAAGTCAAACCTTTTTGAAAAAAAGAAACACCACGGGCTGGAGAGATGGC TCAGTGGTTAAGAACACTGACCACTCTTCCAGAGGTCCTGAGTTCAATTCCCAGCAACCACATGGTGGCT CACAGCCATCTGTAATAGGATCTGATGCCCCCTTCTGGTGTGTCTGAAGATAGCTACAGTGTATTCATAT ATAAAATAATAAATACATCCTTTTTTTTCTTTTTTTAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_010508
• Insert Size: 1773 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC052217, AAH52217
• RefSeq Size: 3902 bp
• RefSeq ORF: 1773 bp
• Locus ID: 15975
• UniProt ID: P33896
• Cytogenetics: 16 52.98 cM
• Gene Summary: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).[UniProtKB/Swiss-Prot Function]