Sh2b3 (NM_008507) Mouse Untagged Clone

CAT#: MC203727

Sh2b3 (untagged) - Mouse SH2B adaptor protein 3 (Sh2b3), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Sh2b3
• Synonyms: AI429800; L; Lnk
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC006759
  GATGGGCTCGGGCCGTCGCCTCCGCCTGGCCGCTCTCCAGCCCAGACTGTCACGGGCCACACGGGGTCCA CATCGGCGGCGGCAGCAGCAGCAGCGTCCTGGGGACGGCCCGAGGCCGCGTCCCCCGGCTGCTGTCAGGA GCTGGCGGCGGAAATGAGGCGCTGGCCGTTTTCCGAGCCGGGGTTTCCTGCCTGAGCGCCGAGAGGCCGT GCGACGCCATGGGCCGGCCGGGCCCCGACCCGCAGCTTGCGCGCCCGGCCGCCCCGCCTCGCTCTCCACC ATGAACGAGCCCACCGTGCAGCCGTCCCGCACATCCTCCGCACCCGCCTCGCCGGCATCCCCACGCGGCT GGAGCGACTTCTGCGAGCAGCACGCAGCAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGTTGTTTGC GCGCGCGCACCCACAGCCGCCGCGCGCGGACCTGGTGTCGCTGCAGTTCGCGGAGCTCTTCCAGCGCCAC TTCTGCCGGGAGGTGCGCGAGAGCCTCGCAGGACCGCCGGGTCACGACTACCGCGCCACTGCTCCGCCCC GCCCCGCGCTGCCCAAGGCACGCAGCTCCGAGGACCTGGGCCCGCGGCCCGCCTGTGCCCTGCAGCACCT GCGCCGCGGCCTGCGCCAGCTCTTCCGCCGCCGCTCGGCAGGGGAGCTGCCCGGGGCTACCAGTGACACC AATGACATCGACACCACCGCAGCCAGCAGGCCGGGCCCGGCCCGCAAGTTGCTACCCTGGGGCCTGCGAG AGCCGCCCACTGAGGCGCTCAAGGAGGTCGTATTGCGCTATAGCCTGGCGGACGAGGCAGCAATGGACAG CGGCGCACGCTGGCAGCGGGGTCGCCTGGTGCTTCGGTCTCCAGGTCCGGGCCACAGCCACTTTCTGCAG CTCTTCGATCCGCCCAAGAGCTCAAAGCCCAAGCTCCAAGAGGCCTGTTCCAGCATCCGGGAGGTCCGAC CATGTACACGCCTGGAGATGCCTGACAACCTCTACACCTTTGTGTTGAAGGTGCAGGACCAGACAGACAT CATCTTTGAGGTGGGAGATGAACAGCAGCTGAACTCATGGCTGGCAGAGCTCAGGGCAAGCACAGGCCTT GGGCTGGAGCACCCGGACACCGAGTTACCTCTTTCCTTAGCGGCAGAGCCTGGCCCAGCTAGATCCCCAA GGGGAAGCACTGACTCCCTGGACCAAGGTGCTTCACCTGGGGTGTTGCTGGACCCAGCCTGCCAGAAAAC AGATCACTTCCTATCCTGCTACCCCTGGTTCCACGGCCCCATCTCCAGGGTGAGGGCTGCACAGCTGGTC CAGCTCCAGGGCCCTGATGCCCACGGCGTGTTCCTGGTGCGGCAGAGTGAGTCCCGGAGAGGAGAGTATG TACTCACATTCAACTTACAGGGCAGAGCCAAGCACTTACGCCTGGTGCTCACAGAGCGTGGACAGTGCCG GGTGCAACACCTGCACTTCCCCTCGGTGGTAGATATGCTCCGCCACTTCCAGCGTTCTCCTATCCCACTG GAATGTGGAGCAGCTTGTGACGTCCGACTCTCTGGCTATGTGGTAGTCCTCTCTCAGGCACCAGGTTCCT CCAACACCGTCCTCTTCCCTTTTTCCCTTCCTCACTGGGATTCGGAGCTGGGTCATCCCCACCTCAGCTC TGTTGGCTGTCCCCCCAGCCATGGTGCAGAGGCTCTCCCTGGCCAAGTGACACCACCTGAGCAGATCTTC CACCTGGTGCCTTCTCCTGAGGAACTGGCCAACAGTCTGCGGCAGCTGGAGCTCGAGTCTGTGAGCAGTG CCCGGGACTCGGACTATGACATGGACTCCTCTTCACGGGGCCACCTTCGGGCCATTGACAACCAGTACAC CCCTCTCTCACAGCTGTGCAGAGAGGCAGACGTGTGAATGGAACCATTTTCCTCCCCTCCAGAGAACTAT AGGCTGCTGTCAGCCTTCCCCAGCTCAGATGTGCCCCGCTTCCAACACACACAAGGCTGTCACAGGCTTC CTGTCAGCCAGAGCTAGCCCCCGGCTTTCTCCCACTGTTTACAGATGTAGTTCTTGTGCACAGGTGCCAC TAGCTGGTACCCTAGGCCTAGTCCCCAACCCAAAAGGAGGTGGGGCTACAGGCCCAGAGCTGGCAGTGGA AACTGACAGAGCTGATGACAGACTTCTTACCAGGCAGGGTCATCGGGAAGCACAAAACACTAACAGTCCC TGGATTCTCACATGGTGTCCTTCCCTGTAGCTTCAGATCTGTGGCAAGTCCTCATGGGTTCCATGCCACA GGCGATGGATGCTTCATGATCCTGCTCCTACTCTTAGCTTTACGACAGAAGCTCTGCCAGAGGGACAAGC TTAAAGATCAAAATTGATTTAAACATTTTACCTCAGAGTACTTTTTTTTGTTTTGTTTTAAAGGATTCAG GTTTCCATTTAATATTAAAGCTTATTCACTGCAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_008507
• Insert Size: 1647 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC006759, AAH06759
• RefSeq Size: 2499 bp
• RefSeq ORF: 1647 bp
• Locus ID: 16923
• UniProt ID: O09039
• Cytogenetics: 5 61.99 cM
• Gene Summary: This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
  Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 3 encode the same protein (isoform 1).