Zbp1 (NM_021394) Mouse Untagged Clone

CAT#: MC203115

Zbp1 (untagged) - Mouse Z-DNA binding protein 1 (Zbp1), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Zbp1
• Synonyms: 2010010H03Rik; Dai; Dlm1; mZaDLM
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC020033
  CTGGTGCCTGCAGGTCCAAGCAGCCATTCTTGCCTGTGGATTCAGAGCCCCAGGCCTGACCACAGTGCCA GAAACTGCCACCCCCTGCCCTAAAGGAGCCCCAAGGCTGCTGTGAGCATGGCAGAAGCTCCTGTTGACTT GAGCACAGGAGACAATCTGGAGCAAAAGATCCTGCAGGTGTTGAGCGATGACGGCGGCCCTGTGAAGATT GGCCAGCTGGTGAAGAAATGCCAAGTGCCCAAGAAAACCCTCAATCAAGTCCTTTACCGCCTGAAGAAGG AGGACAGAGTGTCCTCCCCAGAGCCTGCAACATGGCGCATAGGCGGGGCTGCTTCCGGAGATGGGGCTCC TGCAATCCCTGAGGACTCCAGTGCCCAGCCTAGCCTTGATGAAAGAATATTAAGATTCCTGGAAGCCAAT GGGCCTCACAGGGCCCTGCACATCGCCAAGGCTCTGGGAATGACGACAGCCAAAGAAGTGAACCCACTCC TGTATTCCATGAGAAATAAGCACCTTCTGAGCTATGACGGACAGACGTGGAAGATCTACCACTCACGTCA GGAAGGCCAAGACATAGCTCATTCTGGAGTCACACAAGAGTCCCCTGCGATTATTTGTCAGCACAATCCG GTCAACATGATCTGCCAACAAGGAGCCAACAGCCACATCTCCATTGCCAATTCAAACGCCATCCAGATTG GTCACAGGAATGTCATAGTAAGAGAGAAAGCCTGTGGTGAGCCAGGTCCCAGGACCTCTCACCCTCTACC CTTGGCATGGGACGCCTCTGCTCAGGACATGCCCCCTGTTGCCCATGGAGCTCAGTACATCTACATGGAC AAGTCCTTGCTCCAACAAGTGCAGCTTGGCCACCACAACGAGATGAGCCTCGTGGGGGATGCAGGGAAGC ACCCCTCTTATAGCTTTTCTGACAGCCCCCCAGAAGTGTCAACCACCACTGCTGACCCAGGAGCTTCATT CAACATGCAAACATCTGAGCCAGGCCCTCACCCTGAGGGAGACACAGTCCAGACAGTCCACATCAAATCC TGCTTTCTAGAGGACGCCACCATTGGTAACGGCAACAAGATGACCATCCACCTTAGGTCAAAGGGTGAAG TCATGGAGTCTGGAGACAGTGAAGAGCCGAAGAAGGAAGACACAGGTACAAGCTCTGAAGCCACTCCACC CAGAAGCTGCCAGCACACGCCCAGTGACTCCATGCTGCCCACCTCTGAGCTGAGAGCTATGGCTCTGGGA GACAGTAGCCCCCAGACCACAGAACCTGTGCTTAGAGAGCATGAAGTCCAGGACATAGAAAGCACTCAAG ACACAGGACTGAGCAAGCAATGAAGCTGTGGGACCATAGGCTGACCCCTCTGCCACTATAAGTCAAATCA ACCTTTCCTGCCTCAAGATCAATCAATCAATTAACCACAGGAGCAGTTCTACCACTCCTGGATGCTCACC CAAAGGCAAAAGTCAACACAGAGAGATCTCCGCATATCCATGTAGATTGGGATACTGTTCACAGCAGCTA AGAAGTGGAACCGACCTTGCTACCCAGCAGTAAAAGATGGGTGAATTGGAGTATGCACACAGCCATGGAA AATACTGAGGCTGTCACTGGCCAGAAGAGGATGTGACCAGAGGCCACCATGTTGAATGAATGAAAGCCAT CTTAGAAAGACAAGGGCCACATTTTCTCTGTTGTGGCTCCTAGACTTTAGATAGATTTATAAGATCATAT ACACAGATGTGACATGGAAGTACATGTAACACCAACCAGGGGATGAGGATGGTGCATGGGGAGGAGAGGC GGGGGTCACAGCCTGGGGGGGGGTCACGGCCAAGGGGGGGTCATGGTCTGGGAGGGTGTCACCACCTAAA GAGATCACAGCTGGGGGGGATCAGGGCCGGGAGGGGGGACACTGCCGAATGTACTGTACTTTTATAAAAA GGCGTACCTCTGAATAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_021394
• Insert Size: 1236 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC020033, AAH20033
• RefSeq Size: 1990 bp
• RefSeq ORF: 1236 bp
• Locus ID: 58203
• Cytogenetics: 2 H3
• Gene Summary: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because C57BL/6 strain transcript sequence from the C57BL/6 strain consistent with the reference genome assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.