Fbxo38 (NM_134136) Mouse Untagged Clone

CAT#: MC202553

Fbxo38 (untagged) - Mouse F-box protein 38 (Fbxo38), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Fbxo38
• Synonyms: 6030410I24Rik; AU044865; AW214031; Moka; SP329
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC056348 sequence for NM_134136
  ATTCTCGGTCCCTCTCCACCACAAAAACAGACGGAGGGCCGGCGTAAGTGAGCCGCGGCCTGGGAGGCTG TCGCGACGGTGGAGGTATTTTGAACTAACTTTGACACTGAGGGAGCACAGCCATGGGACCACGAAAGAAA AGTGCTAAAGTGTGTGTGATGGACAGTGAGGTCGCTGAGGAAATGACAGCCGATGAAGAGAAGGACTACA TGAACCAGCTGTCACATGAAGTGCTCTGTCATATCTTCAGGTACCTGCCACTACAGGACATCATGTGCAT GGAATGCCTCTCTCGGAAGCTAAAGGAGGCAGTCACTCTGTATCTGAGAGTTGTCAGAGTGGTGGATCTC TGTGCAGGGCGCTGGTGGGAATATATGCCAAGTGGCTTCACAGATTCCAGTTTCCTAACCCTTTTGAAGA AGATGCCAGATGTTGAACAGCTGTATGGCCTTCACCCTAGATACCTCGAGAGGCGAAGAGTGAGGGGCCA GGAGGCTTTCAGCATCCCAGGAGTCTTGGAAGCTTTGCAAGCGTGCCCAAACTTGGTGGGTGTAGAAACA TCTCATTTGGAGTTGGTAGAATCCATTTGGACATATATGCCGCATGTTCATATTTTGGGGAAATTTCGTA ATCGTAACGGAGCATTTCCGATTCCTCCTGAAAATAAACTGAAAATCCCCATAGGAGCCAAAATCCAAAC TTTGCATTTAGTTGGTGTCAATGTTCCTGAAATCCCTTGTATCCCTATGCTAAGGCACCTGTACATGAAG TGGGTGAGACTCACTAAACCACAGCCGTTTAAAGATTTCCTTTGCATCAGCTTGCGAACTTTTGTCATGA GGAACTGTGCAGGACCAACAAACTCCTTGAAATACGTGCCCTTGGTAACAGGTCTGGCATCTGCCCGTAA CCTGGAACACTTGGAAATGGTTCGAGTCCCTTTCCTGGGAGGTCTCATCCAACACGTGGTTGAAGACAGC TGGAGATCAGGTGGTTTTAGGAACTTGCACACTATTGTCTTAGGAGCTTGCAAGAATGCCCTGGAAGTAG ACCTTGGCTACCTCATCATCACTGCTGCGCGAAGGTTACATGAAGTTCGCATCCAGCCTTCTTTAACCAA AGATGGTGTCTTTTCTGCCCTAAAGATGGCAGAATTGGAGTTTCCCCAGTTTGAAACCCTTCATCTGGGA TATGTAGATGAGTTCTTGCTACAGAGCAGAATGGCGAATGCAGATTTGGTGAAGTATGGCTTGGCTGATG TGGTAGAAAATCCTGGTATCATTACTGATATAGGGATGAAGGCAGTCAATGAAGTTTTTTCCTGTATCAA ATATCTGGCAATTTATAACTGTCCTCATCTACACAACCCATACAATTGGATCTCAGACCACTCGAGGTGG ATGCGACTGGTTGATATCAACCTCGTGCGGTGCCATGCTTTGAAGCTGGATTCTTTTGGCCAGTTTGTTG AATTATTGCCCAGCCTGGAATTTATTTCTCTGGACCAGATGTTCCGTGAGCCACCCAAGGGCTGTGCTCG AGTTGGTCTGAGTGCAGGAACTGGAATTGGGGTTTCCTCAGCGCTTGTCAGCAACCAGAATTCCAACAAT GACAATGACAATAATGCTCCAAATAACAACGCCAACCTCCATGATAACAATCACCATCACCCAGATGATT CGGATGACGACAATGACTTTCGTCCAGACCTACAAGCAGGAGAGGCACAATTTGCAGCCGATGCGTTGAA TGAGATGGAAGACATGGTCCAGGAAGATGGAGAACTGGTAGCCGAGAGTGGAAATGGTATGCCAGCTCAC AATCGGGAAGTTCTTCCTGTGGATGCTGATGAGGAACAAGCAGGACCTAGTGGTCTACAACGCGTGGTAA AACCTACACCAATTGCTGATCACGATTCAGAGAGCGATGATGAAGAAGATAGTTTAGAACTCCAAGAAGT CTGGGCTCCTAAGAATGGCACCCGGCGTTACTCAGAGCGGGAAGAAAAGACTGGAGACTCAGGACAGTCC AGGGAAACGGCAGTAAGTGGGAAAGGCAAGACTCCACTTCGAAAGAGGTGCAACAACTCCCACCAGACGG GCCAGGCGAAGCCGTTTCCCCTGGAGGAGAGCAGCTGTGAGAAAGGCTGTCAGGTGACCAGTGAGCAGAT CAAAGCCGATATGAAAGCAGCTAGGGATGTTTCTGAAAAGAAAAAATCCAAGGATGTCTATCCCAGCTGC AGCAGCAGCAGCAGCAGCACAGCCGCCAGCACAGCGGGAAACGCCAGCTCACCCAGCACTGCTTCCCAGA GCCCGGACTTTGCAAGGACGGTGACCAGCAGCGGCTCTTCCGAGCCGAGCCCTCCAGAAGTAGATGTATC CAGGCAGTGTGTCTGCTCCCCTGGTGGGTCAGAGGACTCTGAGGCCATGGAGGAGGGAGATGCAGAGAGC TCTGTCTGCCCCAGATGCTGCTGTCTCAGGCCCCAGGAGTCTCAAAGGAGAACTGGCAGGTGTTCTGATG AGGAGCGTCCTTCAACCAGCCGAGCCTGTGTTGTGAATGGCGCGGATGGTACGAGATCCGCCTTTTCCTT TAGGACTCTGCCACAAGGGGGGTCTTCAGGCCCAGCACATGATGAGAGGACTAATGGGAGTGGCTGTGGG GCTACAGGTGAGGACAGGAGGGGGAGCTCCCAGCCTGAGAGTTGTGACGTGCAGTCTAATGAAGACTATC CTCGGAGGCCCCTAACCAGGGCCAGGAGCAGACTGTCCCATGTACCGCTGATATCTGAGTCAGAAGTTGC CAAAACAAAGCCATGCCATGCCATGAAACGAAAGCGAACTGCAGATAAGTCTACCAGCACCAGTGACCCT GTGATTGAAGATGACCACGTACAGGTTCTTGTATTAAAATCCAAAAATCTTGTTGGAGTCACAATGACCA ATTGTGGAATCACAGATCTAGTACTGAAAGACTGCCCCAAGATGATGTTCATCCATGCTACCAGGTGCAG GGTACTGAAGCATTTAAAGGTAGAAAATGCACCAATTGTAAACCGATTTGACTATGCACAGTGCAAGAAA CTAAATATGGACCAGGTACTAGACCAAATACTGAGGATGCCTCCGGAGAGGAACCGGATCATCTACCTGC GCCCAATGCAGCAGGTAGACACACTAACTCTGGAGCAGAAGCTCTTCAGCGGGCCCTACCCCTATCACAT CTGCATCATCCACGAGTTCAGCAATCCTCCCAACGTGCGGAACAAGGTGCGCATCCGCAATTGGATGGAC ACGATAGCCAACATCAATCAAGAGCTCATTAAATACGAATTCTTCCTGGAAGCCACTCGGACTGAAGAGG ATTTAAAGAAGTACCCTAAGTATCCCTGGGGGAGAGAAATCTACACTTTAGAGGGTGTTGTAGATGGAGC GCCGTATTCCATGATTTCCGACTTCCCTTGGCTGAGGTCACTGCGGACCGCAGAGCCCAACAGCTTTGCC AGATATGATTTTGAAGATGATGAAGAGAGCACCATCTATGCTCCTCGAAGAAAAGGGCAGTTGTCTGCAG ACATTTGTATGGAGACAATAGGAGAGGAGATCTCAGAGATGCGCCAGATGAAGAGGGGCATATTTCAGCG AGTAGTAGCGATTTTTATCCACTACTGTGATGTCAATGGAGAGCCAGTTGAAGACGACTACATTTAAGTA GACTTTTCCTGGCTCTTCTGGCCCAGAGCAGCCAAGAGTCTCTACACAGGAACCTTGGGCTTGGAATTGG GAGGCCCTGGCTCAGTTTGTTATATAGGAAATATATAAGGAACATGGAAATTGTATACAAAGATTTATAT ATAGAAGAAATATACAAAGATACTTCCAAATGTAACATCTTTATATCCTATGTTTATACATCTTAATTTA AAGACGTCATTTGAAGGCAGGCAAATCGTTTAGCAGTGGTCGTGTTCTTTTCCTGACTTAGTTCTCAGTG TCAGGCGACTGAGCCTATTGCCTCTGCTCCTCACCACGTCCTTCAGTCTGTGCCTTTTTCTTCTCCAGCA GAGCTGTTTGAGTCACCCTCCTAAAGAGTGTTGTATCTTGTGTGTTTTTGTTACCATGATGCCAACTAAA CCCTTAGTCAGAGAAGATTATGTTTCTGCACTAAGATGTGGCTCTTCTTTTTTGTGTGTTTATATTTGGC ATATTCATTTACATGAAAAGATTGACGAACTTAAATAAATTTGAAGGGCAAATAAAAAAAAAAAAAAAAA AAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_134136
• Insert Size: 3585 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC056348, AAH56348
• RefSeq Size: 4280 bp
• RefSeq ORF: 3585 bp
• Locus ID: 107035
• UniProt ID: Q8BMI0
• Cytogenetics: 18 E1
• Gene Summary: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251).[UniProtKB/Swiss-Prot Function]