Klhl2 (NM_178633) Mouse Untagged Clone

CAT#: MC202127

Klhl2 (untagged) - Mouse kelch-like 2, Mayven (Drosophila) (Klhl2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Klhl2
• Synonyms: 6030411N21Rik; ABP-KELCH; AU020744; Mav
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC031144 sequence for NM_178633
  GGGGCCGCCGCCGCAGGTGGTGGCGCGCGGTGAGGAGCGCTGCGCCCCCTCGGGGCGGATGGAACGGGGC TGGGCGGGCGGACAGTGCCGGCGTCCGCGGCTGGTATGGTGCTGGCGGCGGCGGTCGCTGCCTGCGTTCT GAAGCCCGCGAGGAGCCACAATGGAGACGCCGCCACTGCCTCCCGCATGCACAAAGCAGGGTCATCAGAA GCCCCTCGATTCAAAAGACGAGAATCCTGAGAAACATTGCCCACTGACGGTGAACCCCTGGCACATGAAG AAAGCCTTTAAAGTCATGAACGAACTCAGAAGTCAAAATCTGCTGTGTGACGTCACGATTGTGGCAGAAG ACATGGAGATCCCTGCTCACCGCGTGGTGCTGGCGGCCTGCAGTCCGTACTTCCACGCCATGTTTACAGG TGAGATGAGCGAGAGCCGAGCAAAGAGAGTTCGAATAAAGGAGGTGGACGGCTGGACCCTGAGGATGCTG GTCGATTACGTTTACACGGCAGAGATTCAGGTCACAGAGGAGAACGTGCAGGTCCTCCTCCCAGCAGCTG GCCTGCTACAGTTACAGGATGTGAAGAAGACATGCTGTGAATTTTTAGAATCCCAGCTTCACCCTGTCAA CTGCTTAGGAATCCGGGCTTTTGCTGATATGCATGCATGCACAGACCTCCTGAATAAGGCCAACACGTAT GCAGAACAACATTTTGCAGATGTCGTACTTAGTGAAGAGTTTCTTAACCTCGGCATCGAGCAGGTGTGCA GCTTAATCTCCAGTGATAAACTCACCATTTCCTCCGAGGAGAAGGTATTTGAAGCAGTCATCGCCTGGGT AAACCACGATAAGGACGTAAGACAGGAGTTCATGGCTCGGCTCATGGAGCATGTCCGATTACCTCTGCTT CCTCGGGAGTACTTGGTGCAGCGGGTTGAAGAGGAAGCATTGGTGAAGAACAGCAGTGCGTGCAAAGATT ACCTCATTGAAGCCATGAAGTACCACCTGCTGCCGACAGAGCAGCGCATGTTAATGAAGAGCGTGCGGAC CCGCCTGAGGACGCCCATGAACCTTCCCAAATTGATGGTGGTGGTCGGGGGCCAGGCACCAAAGGCTATC CGAAGTGTGGAATGCTACGACTTCAAAGAAGAACGGTGGCACCAGGTGGCAGAGCTGCCTTCCAGGAGGT GCAGGGCAGGGATGGTCTATATGGCTGGGCTGGTCTTTGCTGTTGGTGGCTTCAATGGCTCACTAAGAGT TCGCACTGTAGATTCCTATGACCCCGTGAAAGACCAGTGGACCAGCGTGGCGAACATGCGAGACCGAAGA AGCACACTTGGAGCCGCGGTGCTGAATGGGCTGCTGTACGCCGTGGGGGGCTTTGACGGCAGCACAGGTC TATCGTCTGTGGAAGCATACAACATAAAATCTAATGAGTGGTTTCATGTCGCCCCAATGAACACGAGGAG GAGCAGTGTGGGTGTTGGCGTTGTTGGAGGTTTGCTCTATGCCGTGGGGGGTTACGATGGAGCATCGCGC CAGTGTCTTAGCACAGTAGAATGCTATAATGCTACTGCAAACGAGTGGACTTACATAGCAGAAATGAGCA CCAGACGGAGCGGAGCAGGTGTTGGTGTGTTAAACAACTTATTATATGCTGTAGGAGGTCATGATGGTCC TTTAGTACGAAAAAGTGTTGAAGTATATGACCCCACCACAAATGCCTGGAGACAGGTTGCAGATATGAAC ATGTGCAGAAGAAATGCAGGTGTCTGTGCAGTTAATGGTCTGTTGTATGTTGTCGGAGGAGATGATGGTT CCTGTAACTTGGCGTCGGTAGAGTATTATAACCCCACCACGGATAAATGGACAGTTGTGTCCTCTTGTAT GAGCACGGGGAGAAGCTACGCAGGGGTCACAGTTATTGATAAACCGTTATGAGCCTGAAGGACATTTTCA GCGTATCATTCCATGAGAACCAGGCGTCCACAAGTATTTCTGAAGGGACTGAGCGCCTGGCCTCTCCACT TGTAGCCGCACTTTACGTCTCAGCAGAAGATGAGACCATCTGCCTTCAGAGGCCTCGGATACTGAAGATT ATTTTTGGTAGAAGCACTGTGTAGGCTTTCTCTGCACCGAGCAGCAGCTGACTGACTTTACAAGAGACCT AGACTGCAGTCCCTCCACTGTGGTCTTTAGGCAACAGTCGCTTTCATAAAAACTAGTTCTTATCAGCCTC GAATGACTATGGATTATTTTGTGAAAGAGAATAAAGTTAACGTGTGTTCTTGTAAAATTAAGTTTTATCT TTATTCTTTCTCCTGAAAAATCTCCTGGGAACAGAGAATCTTTGGAGCAGATTAAAATCTATGTAAGTAT ATGACACTGTTGAGGGGTGAAACTGCTGGCTTTTATAAGTATCTTTGATTACATGACTATAATAAATTGT GTGCATATAAATGTGTGTCTATATGCTTTCCTTTAAATATGTTTGAAAAGATGTTTGATTATCTATTTAT AATTGGCACAGTACTTTGAATTATGCCAGTACTACATTGTAAAACAGAGTTGTATTTTTTGATATTTAAC AATGCTGAACACTTTAAAAAACGCCACTTCTGAGGAATGAATGAACATGGCGTAACACACTTTAATATGT GTGATGCCAAACTTTTTTAAATAAAATATAAATTATGCTTATTTATTATTTTTTTCTTTAGTTTAATCTT GATCATGTTTTGGTGTGTGTTTTTAATTTTTTTTCTTAAAGTAACACTTTTGGCATGAACATACCTGCAG GTTTTTTGATGAATATAATGAATGTGTGGAATTCAACTGAATTTGCATGGTCTTAAGAATTTTTTCTGTG TGTATAAATTTAGCTGCTATTAATGGAAGAGAAAGCTTTCTGTGACTAATCATGTGTATTGAGCAGATAG TTTTTCTGAGATCTTCGATTAATCTCTTTAAAGATGACCAACATGTGTCTTTCTTGAATTATCTTTGAAT AAAAGTTTGTATATTAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_178633
• Insert Size: 1782 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC031144, AAH31144
• RefSeq Size: 3040 bp
• RefSeq ORF: 1782 bp
• Locus ID: 77113
• UniProt ID: Q8JZP3
• Cytogenetics: 8 B3.1
• Gene Summary: Promotes growth of cell projections in oligodendrocyte precursors. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Plays a role in the reorganization of the actin cytoskeleton.[UniProtKB/Swiss-Prot Function]