Dpp4 (BC022183) Mouse Untagged Clone

CAT#: MC200935

Dpp4 (untagged) - Mouse dipeptidylpeptidase 4 (cDNA clone MGC:14076 IMAGE:3982742), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Dpp4
• Synonyms: Cd26; Dpp-4; THAM
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC022183
  CCACGCGTCCGGTCTCTTTTAGCAAAGGGGGTTCGCTGTTCCCCTTATCCCTCACTCATGGGGGCCCTGC GTGCTACTTCCTGGCTCGCCTAGTGGTCCTACCGCGCTGGGTCGGCTGCCCCGCGCTCACACTGTGCACC GAAGCCCGCCTTGCGCTAACTAATGTTTAACTCAGGCCGAAACTTGGCGGCGAGCTCAGGGTGACTGCGT GCAGAGCAGCGGCGCAGGACGTCTGTCTCTGCGCGCAGTGACTTCTGCCTGCGCTCAAGCTACAGAGTTC AGTTTCAAGGAGCCGCCCGACCATGAAGACACCGTGGAAGGTTCTTCTGGGACTGCTTGGTGTCGCTGCG CTTGTCACCATCATCACCGTGCCAATAGTTCTGCTGAGCAAAGATGAAGCGGCAGCTGACAGCCGCAGAA CGTATTCACTAGCTGACTATTTAAAGAGTACCTTTCGGGTCAAGTCCTACTCTTTGTGGTGGGTTTCAGA CTTTGAATACCTCTACAAACAAGAGAACAATATCTTGCTGCTCAATGCTGAACATGGAAACAGCTCCATT TTCTTGGAGAACAGTACCTTTGAAAGCTTTGGATATCATTCAGTGTCACCTGACCGACTGTTTGTTCTCT TGGAATACAACTACGTGAAGCAATGGAGACATTCCTACACAGCTTCATACAACATTTATGATGTGAATAA AAGACAGCTGATCACAGAAGAGAAGATTCCAAATAATACACAGTGGATCACATGGTCACCAGAAGGTCAT AAGTTGGCATATGTCTGGAAGAATGATATTTACGTTAAAGTTGAACCACACTTACCTAGTCATAGGATCA CATCGACAGGAGAAGAAAATGTAATATATAATGGAATAACTGACTGGGTTTATGAAGAGGAAGTCTTCGG TGCCTACTCTGCACTGTGGTGGTCTCCAAACAACACGTTTCTAGCTTATGCCCAGTTTAACGACACAGGA GTGCCGCTCATTGAATACTCCTTCTATTCTGATGAGTCACTGCAGTACCCCAAGACAGTGTGGATTCCAT ACCCAAAGGCAGGAGCTGTGAATCCAACTGTAAAGTTCTTTATTGTAAATATAGACTCTCTCAGCTCATC CTCTAGTGCGGCTCCCATCCAAATCCCTGCTCCTGCATCTGTGGCAAGAGGGGATCACTATTTATGTGAT GTGGTGTGGGCTACAGAAGAAAGAATTTCACTACAGTGGCTCAGGAGGATTCAGAACTATTCCGTGATGG CTATCTGTGACTATGATAAGATCAACCTAACGTGGAACTGTCCATCCGAGCAGCAGCACGTTGAAATGAG TACCACGGGCTGGGTCGGAAGATTTAGGCCCGCAGAACCTCACTTCACCTCTGATGGAAGCAGCTTCTAT AAGATCATCAGCGACAAAGATGGCTATAAACACATCTGCCACTTCCCGAAAGATAAGAAAGACTGTACAT TTATTACAAAAGGAGCCTGGGAAGTCATTAGTATCGAAGCTCTGACCAGCGATTATCTATACTACATTAG TAACCAATATAAAGAAATGCCAGGAGGAAGAAATCTCTATAAAATTCAACTTACTGACCACACAAATGTG AAGTGCCTTAGTTGTGACCTGAATCCAGAAAGATGTCAGTATTATGCAGTATCATTTAGTAAAGAGGCAA AGTACTATCAGCTGGGATGTTGGGGCCCCGGTCTGCCCCTCTACACTCTACATCGTAGCACGGATCATAA AGAGCTGCGAGTCCTGGAAGACAATTCTGCTTTGGATAGAATGCTGCAGGATGTCCAGATGCCTTCAAAA AAATTGGACTTCATTGTTTTGAATGAAACAAGATTTTGGTATCAAATGATCTTGCCCCCTCATTTTGATA AATCCAAGAAATATCCTCTACTATTAGATGTATATGCAGGTCCCTGTAGTCAAAAAGCAGATGCTTCCTT CAGACTGAACTGGGCCACTTACCTTGCAAGTACAGAAAACATCATAGTAGCTAGCTTTGACGGCAGAGGA AGTGGTTACCAAGGAGATAAGATCATGCATGCAATCAACAGAAGATTGGGAACACTGGAAGTTGAAGATC AAATTGAAGCAGCGAGGCAATTTGTAAAAATGGGATTTGTGGACAGCAAGCGAGTTGCAATTTGGGGCTG GTCATATGGAGGGTATGTAACCTCAATGGTCCTGGGATCGGGAAGTGGCGTGTTCAAGTGCGGAATAGCT GTGGCACCTGTGTCACGGTGGGAGTACTATGACTCAGTGTACACAGAGCGTTACATGGGTCTCCCAATTC CAGAAGACAACCTTGACCATTACAGGAACTCAACAGTCATGAGCAGAGCTGAACATTTTAAACAAGTTGA GTACCTCCTTATTCATGGAACGGCAGATGATAATGTTCACTTTCAGCAGTCAGCTCAGATCTCCAAAGCC CTGGTGGATGCTGGCGTGGATTTCCAAGCAATGTGGTACACGGATGAAGACCACGGGATCGCTAGCAGCA CAGCTCACCAGCACATCTATTCCCACATGAGCCATTTCCTCCAGCAGTGCTTCTCCTTACACTAGCACAG CATAGCTCTCCATAGCTTATTTAAGACCACATTTGTTCTCATTATCTCAAAAGTGCACTGTTAAGATGAA GATCTTAATAATGTTGCATTGAGACATTTCAGGCTGCTTTCTCCAGTTTTACACCTGCAATCCTAACTAA GGATGCCTGTCCCCAGAACAGATTACTACCTTAGAGCAATTTGGATTTTCCCCTCTGTTTTGTTTATCAT TTAAAATCATTTCCACATCAGCTGCTGAAACAACAAATATAAATTATTTTTGCAAGAGCTATGCATAGAT TTCCTGAGCAGAATTTCAATTTTTTTTTTTTCCTTACTAGACTGGTCCAAATCTCGTTTCCCTTATTTAA GTGGGTGACAAGATGTGGGTAATGATGTCATTAGGGCAGCAACAAGAGAAGAGGGAGCAGGGAGTATGGC TAGAAACCCAGGTCCAAGCATACAAACCAACCAGGCTACTGTCAGCTCGCCTCGAGAAGAGCTGTTCACT GCCAGACTGGCACAGTTTTCTGAGAAAGACTATTCAAACAGTCTCAGGAAATCATATATGCAAAGCACTG ACTTCTAAGTAAAACCACAGCAGTTGAATAGACTCCAAAGAAATGCAAGGGACGCTGCCAGCAATGTAAG GGCCCCAGGTGCCAGTTATGGCTATAGGTGCTACAAAAACACAGCAAGGGTGATGGGAAAGCATTGTAAA TGTGCTTTTGAAAATTACCGATGTCTCCTAGTGAAAAGAGGCAGCTTGGAACATATCGACTTGCCCTGTT AAAAGTTGAAAATATTTGTGTCACAAATTCTAACATGAAAGAATACTTGCATTAGTTTTTCCTACTTCAT TTCTTTGAGCATTTTAATTAAAATATTTTAACTTCAAAAAAAAAAAAAAAAG
• Restriction Sites: RsrII-NotI
• ACCN: BC022183
• Insert Size: 2283 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC022183, AAH22183
• RefSeq Size: 3482 bp
• RefSeq ORF: 2283 bp
• Locus ID: 13482
• Cytogenetics: 2 35.85 cM
• Gene Summary: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.[UniProtKB/Swiss-Prot Function]