ERG Mouse Monoclonal Antibody [Clone ID: UMAB77]

CAT#: UM500065

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ERG mouse monoclonal antibody,clone UMAB77



  View other "UMAB77" antibodies (2)

USD 564.00


Availability*
In Stock

Size
    • 100 ul


Specifications

Product Data
Clone Name UMAB77
Applications 10k-ChIP, IF, IHC, WB
Recommended Dilution IHC 1:100
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human ERG(NP_891548) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 53.7 kDa
Gene Name Homo sapiens ETS transcription factor ERG (ERG), transcript variant 1, mRNA.
Background This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan
Synonyms erg-3; p55
Reference Data
Protein Families Druggable Genome, Transcription Factors

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