Granulin (GRN) Mouse Monoclonal Antibody [Clone ID: OTI3B3]

CAT#: TA807351

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GRN mouse monoclonal antibody, clone OTI3B3 (formerly 3B3)



  View other "OTI3B3" antibodies (4)

Special Offer: Try sample size of this antibody at $99/€99. Use code “TrueSample”.

USD 417.00


Availability*
In Stock

Size
    • 100 ul


Specifications

Product Data
Clone Name OTI3B3
Applications IHC
Recommended Dilution IHC 1:150
Reactivity Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 327-593 of human GRN(NP_002078) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 61.7 kDa
Gene Name granulin
Background Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
Synonyms CLN11; GEP; GP88; PCDGF; PEPI; PGRN
Reference Data
Protein Families Druggable Genome, Secreted Protein

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