PBX1 Mouse Monoclonal Antibody [Clone ID: OTI1D9]
PBX1 mouse monoclonal antibody, clone OTI1D9 (formerly 1D9)
Product Datasheet for 'TA502971'
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|Applications||FC, IF, WB|
|Recommend Dilution||WB 1:2000, IF 1:100, FLOW 1:100|
|Immunogen||Full length human recombinant protein of human PBX1 (NP_002576) produced in HEK293T cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||46.4 kDa|
|Gene Name||PBX homeobox 1|
|Background||This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Protein Families||Druggable Genome, Stem cell - Pluripotency, Transcription Factors|