COX8C Rabbit Polyclonal Antibody

CAT#: TA371698

COX8C rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA371698 (COX8C Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using TA371698 (COX8C Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA371698 (COX8C Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA371698 (COX8C Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human prostate cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human COX8C
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: cytochrome c oxidase subunit 8C
• Database Link:
  Entrez Gene 341947 Human
  UniProt ID Q7Z4L0
• Background: The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. The COX8 (cytochrome c oxidase subunit VIII) subunits are nuclear and have muscle and non-muscle-specific isoforms. COX8 exists as three isoforms: COX8a, a liver and heart isoform, Cox8b, a heart-specific isoform, and Cox8c, whose expression pattern has yet to be elucidated. All three Cox8 isoforms exists as components of the COX complex and play an important role in electron transport. This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
• Synonyms: COX8-3; MGC119774; MGC119775