SIK1B Rabbit Polyclonal Antibody

CAT#: TA367279

SIK1 rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA367279 (SIK1 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA367279 (SIK1 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA367279 (SIK1 Antibody) at dilution 1/30 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA367279 (SIK1 Antibody) at dilution 1/30, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm or Nucleus
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human SIK1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: salt inducible kinase 1B (putative)
• Database Link:
  Entrez Gene 102724428 Human
  UniProt ID P57059
• Background: SIK1 (salt-inducible kinase 1), also known as SNF1LK or MSK, is a 783 amino acid protein that contains one UBA domain and one protein kinase domain and belongs to the Ser/Thr protein kinase family. Localized to both the nucleus and the cytoplasm, SIK1 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation. Additionally, SIK1 has a potential role in regulation of the G2/M cell cycle transition, as well as in inhibitory control of CREB protein function.