Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody

CAT#: TA360558

ALPL Antibody - middle region

Product Images

Host: Rabbit Target Name: ALPL Sample Tissue: Human Jurkat Whole Cell Antibody Dilution: 1.0ug/ml

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  Host: Rat Target Name: ALPL Sample Tissue: Rat Brain Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ALPL
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 57 kDa
• Gene Name: alkaline phosphatase, liver/bone/kidney
• Database Link:
  NP_000469.3
  Entrez Gene 25586 RatEntrez Gene 249 Human
  UniProt ID P05186
• Background: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.
• Synonyms: AP-TNAP; FLJ40094; FLJ93059; glycerophosphatase; HOPS; MGC161443; MGC167935; OTTHUMP00000002972; TNAP; TNSALP

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways