APEX2 Rabbit Polyclonal Antibody

CAT#: TA358877

APEX2 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: APEX2 Sample Tissue: Human Testicular Tumor lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human APEX2
• Specificity: Expected reactivity: Human
  Homology: Cow: 85%; Horse: 93%; Human: 100%; Rat: 77%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 57 kDa
• Gene Name: apurinic/apyrimidinic endodeoxyribonuclease 2
• Database Link:
  NP_055296
  Entrez Gene 27301 Human
  UniProt ID Q9UBZ4
• Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Synonyms: APE2; APEXL2; XTH2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair