NDUFA1 Rabbit Polyclonal Antibody

CAT#: TA358767

NDUFA1 Antibody - N-terminal region

Product Images

WB Suggested Anti-NDUFA1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal kidney

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep
  Homology: Cow: 85%; Horse: 86%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 79%; Rat: 92%; Sheep: 85%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 8kDa
• Gene Name: NADH:ubiquinone oxidoreductase subunit A1
• Database Link:
  NP_004532
  Entrez Gene 4694 Human
  UniProt ID O15239
• Background: The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function.
• Synonyms: CI-MWFE; MWFE; ZNF183

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease