DUSP4 Rabbit Polyclonal Antibody

CAT#: TA358623

DUSP4 Antibody - C-terminal region

Product Images

WB Suggested Anti-DUSP4 Antibody Titration: 1.0 ug/ml Positive Control: COLO205 Whole CellDUSP4 is strongly supported by BioGPS gene expression data to be expressed in Human COLO205 cells

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
  Homology: Cow: 92%; Dog: 85%; Guinea Pig: 86%; Horse: 92%; Human: 100%; Mouse: 92%; Pig: 92%; Rabbit: 85%; Rat: 92%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 43kDa
• Gene Name: dual specificity phosphatase 4
• Database Link:
  NP_001385
  Entrez Gene 1846 Human
  UniProt ID Q13115
• Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
• Synonyms: HVH2; MKP-2; MKP2; TYP; VH2

Reference Data

• Protein Families: Phosphatase
• Protein Pathways: MAPK signaling pathway