SLC7A5 Rabbit Polyclonal Antibody

CAT#: TA358504

SLC7A5 Antibody - N-terminal region

Product Images

WB Suggested Anti-SLC7A5 Antibody Titration: 1.0 ug/ml Positive Control: Jurkat Whole Cell

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  Host: Rabbit Target Name: SLC7A5 Sample Type: Human HepG2 Antibody Dilution: 1.0ug/mlSLC7A5 is supported by BioGPS gene expression data to be expressed in HepG2

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  Host: Rabbit Target Name: SLC7A5 Sample Type: Human 721_B Antibody Dilution: 1.0ug/mlSLC7A5 is supported by BioGPS gene expression data to be expressed in 721_B

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  Host: Rabbit Target Name: SLC7A5 Sample Type: Human Hela Antibody Dilution: 1.0ug/mlSLC7A5 is supported by BioGPS gene expression data to be expressed in HeLa

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human
  Homology: Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 56kDa
• Gene Name: solute carrier family 7 member 5
• Database Link:
  NP_003477
  Entrez Gene 8140 Human
  UniProt ID Q01650
• Background: SLC7A5 is a sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. SLC7A5 is involved in cellular amino acid uptake. SLC7A5 acts as an amino acid exchanger. SLC7A5 is involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. SLC7A5 plays a role in neuronal cell proliferation (neurogenesis) in brain. SLC7A5 is involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. SLC7A5 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. SLC7A5 may play an important role in high-grade gliomas. SLC7A5 mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. SLC7A5 acts as the major transporter of tyrosine in fibroblasts.
• Synonyms: 4F2LC; CD98; CD98LC; D16S469E; E16; hLAT1; LAT1; MPE16

Reference Data

• Protein Families: Druggable Genome, Transmembrane