MYCNOS Rabbit Polyclonal Antibody

CAT#: TA356963

MYCNOS Antibody - N-terminal region

Product Images

WB Suggested Anti-MYCNOS Antibody Titration: 1.0 ug/ml Positive Control: HepG2 Whole Cell

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  Host: Rabbit Target Name: MYCNOS Sample Tissue: Human Hela Whole Cell Antibody Dilution: 1ug/ml

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  Host: Rabbit Target Name: MYCNOS Sample Tissue: Human SGC-7901 Whole Cell Antibody Dilution: 5ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human
  Homology: Human: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 12kDa
• Gene Name: MYCN opposite strand
• Database Link:
  NP_006307
  Entrez Gene 10408 Human
  UniProt ID P40205
• Background: The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis.
• Synonyms: CYMN; NCYM; NYCM