AIRE Rabbit Polyclonal Antibody

CAT#: TA355555

AIRE Antibody - N-terminal region

Product Images

WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human Liver

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  AIRE antibody - N-terminal region (TA355555) validated by WB using human LCL at 1:1000.

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  Host: Rabbit Target Name: AIRE Sample Tissue: Mouse Skeletal Muscle Antibody Dilution: 1ug/ml

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  Host: Mouse Target Name: AIRE Sample Tissue: Mouse Skeletal Muscle Antibody Dilution: 1ug/ml

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  Rabbit Anti-AIRE Antibody Catalog Number: ARP32650 Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0-8.0 ug/ml Magnification: 400X

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Specifications

Product Data

• Applications: IHC, WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
• Specificity: Expected reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
  Homology: Cow: 92%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 58kDa
• Gene Name: autoimmune regulator
• Database Link:
  NP_000374
  Entrez Gene 11634 MouseEntrez Gene 326 Human
  UniProt ID O43918
• Background: The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
• Synonyms: AIRE1; APECED; APS1; APSI; OTTHUMP00000109529; PGA1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Primary immunodeficiency, Ubiquitin mediated proteolysis