SRPK1 Rabbit Polyclonal Antibody

CAT#: TA355012

Rabbit Polyclonal Anti-SRPK1 Antibody

Product Images

Western blot analysis of SRPK1 in mouse heart tissue lysate with SRPK1 antibody at 1ug/ml.

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  Immunohistochemistry of SRPK1 in human testis tissue with SRPK1 antibody at 5ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1-2µg/mL.IHC: 5µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SRPK1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human SRPK1. The immunogen is located within the first 50 amino acids of SRPK1.
• Formulation: SRPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SRPK1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 54, 72, 91 kDa; Observed: 91 kDa
• Gene Name: SRSF protein kinase 1
• Database Link:
  NP_003128
  Entrez Gene 6732 Human
  UniProt ID Q96SB4
• Background: SRPK1 and SRPK2, two Arginine/serine-rich (SR) protein-specific kinases constitute control circuits to regulate both constitutive and alternative pre-mRNA splicing and coordinate splicing with transcription in cells (1). They are highly specific for the phosphorylation of these RS proteins, and highly expressed in testis (1,2). SRPK1 plays a role in the condensation of sperm chromatin and controls the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis (3,4).
• Synonyms: SFRSK1
• Note: SRPK1 antibody can be used for the detection of SRPK1 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry at 5 µg/ml.