STAT5A Rabbit Polyclonal Antibody

CAT#: TA354958

Rabbit anti STAT5A (pS780) Polyclonal Antibody

Product Images

WB: The whole tissue lysate derived from 30 min posttreatment of 200 uM GH mouse liver was immunoblotted by Rabbit anti-STAT5a (pS780) antibody at 1:500. An major immunoreactive band around ~90kDa was observed.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide surrounding to the epitope -LDSRL-S-PPAGLF-with phosphorylation sites at Serine 780 of STAT5a protein from human, mouse, rat, chicken dog and bovine origins.
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90 kDa
• Gene Name: signal transducer and activator of transcription 5A
• Database Link:
  NP_001275647
  Entrez Gene 20850 MouseEntrez Gene 6776 Human
  UniProt ID P42229
• Background: STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. Activation of STAT5a induces dimerization, nuclear translocation and DNA binding. Stat5A is activated by IL-2, IL-7, IL-15, IL-3, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin; activation and dimerization of Stat5A requires phosphorylation of STATs.
• Synonyms: MGF; STAT5

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Chronic myeloid leukemia, ErbB signaling pathway, Jak-STAT signaling pathway, Pathways in cancer