Corin Rabbit Polyclonal Antibody

CAT#: TA354595

Rabbit anti Corin (NT) Polyclonal Antibody

Product Images

WB: The whole cell lysates derived from mouse heart (lane 1) or rat heart (lane 2) were immunoprobed by Rabbit antiCorin (NT) at 1:500. An immunoreactive band is observed around ~120kDa. A faint band ~ 205 kDa is observed in mouse heart tissue.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the N-terminus (within 60-150aa) of mouse corin protein.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~120 kDa
• Gene Name: corin
• Database Link:
  NP_001116228
  Entrez Gene 289596 RatEntrez Gene 53419 Mouse
  UniProt ID Q9Z319
• Background: Corin, is a glycosylated protease on the cell surface as a single pass type II membrane protein. It is located on trial and brain natriurectic peptides (ANP and NNP) expressing cell surfaces. It may occur in both zymogen and catlytically active forms. The multi-domain transmembrane serine protease corin cleaves pro-atrial natriuretic peptide (pro-ANP) in vitro to generate an active hormone, ANP at R123-S124. Corin is higher expressed on cardiomyocytes. It may also contribute to the regulation of the natriuretic peptide system in vivo, and might be an attractive target for treatment of cardiovascular diseases.
• Synonyms: ATC2; CRN; Lrp4; MGC119742; pro-ANP-convertase; PRSC; TMPRSS10