OAS2 Rabbit Polyclonal Antibody

CAT#: TA349422

Rabbit Polyclonal Anti-OAS2 Antibody

Product Images

Gel: 6%SDS-PAGE Lysate: 40 μg Lane 1-3: A375 RAW264.7 MC3T3-E1 cell lysates Primary antibody: TA349422 (OAS2 Antibody) at dilution 1/300 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 3 minutes

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA349422 (OAS2 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA349422 (OAS2 Antibody) at dilution 1/50, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA349422 (OAS2 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA349422 (OAS2 Antibody) at dilution 1/50, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: A375, RAW264.7, MC3T3-E1 cell lysates
  IHC: 50-200
  Positive control: Human tonsil
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human OAS2
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 82 kDa
• Gene Name: 2'-5'-oligoadenylate synthetase 2
• Database Link:
  NP_002526
  Entrez Gene 4939 Human
  UniProt ID P29728
• Background: This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
• Synonyms: MGC78578

Reference Data

• Protein Families: Druggable Genome